# MMRRC-UC Davis Research on Sex Influences of Genetic Variation Modeling in Female Mice

> **NIH NIH U42** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2020 · $138,639

## Abstract

ABSTRACT
This application for an administrative supplement to NIH Grant U42 OD012210, the parent grant of the Mutant
Mouse Resource and Research Center (MMRRC) at UC Davis, is submitted in response to NOT-OD-20-049
Notice of Special Interest: Administrative Supplements for Research on Sex/Gender Influences. This
supplement will address the first of five objectives of the 2019-2023 Trans-NIH Strategic Plan for Women’s
Health Research “Advancing Science for the Health of Women”: Advancing rigorous research that is relevant
to the health of women. This application proposes pre-clinical research using mouse models of patient-specific
genomic variants as one of three sex-based study types, and includes two of the three proscribed sex-based
research approaches: addition of the opposite sex (in this case, female) and increasing sample size. To do so,
we will conduct the following 3 specific aims: 1) generate cohorts of female mice for variants nominated from
male patients; 2) conduct in vivo targeted phenotyping of female cohorts of mice; and 3) promote awareness
and availability of genetic variants in female mouse models. We propose to study the pathophysiological
consequences of genetic variation in female mice for up to 10 genomic variants we have already studied in
male mice. The purpose of the proposed preclinical research project is to increase mechanistic understanding
of sex differences in phenotypic expression of genetic variants using comparative studies of male and female
physiological systems in mice.

## Key facts

- **NIH application ID:** 10092015
- **Project number:** 3U42OD012210-21S2
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** KC KENT LLOYD
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $138,639
- **Award type:** 3
- **Project period:** 1999-09-30 → 2025-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10092015

## Citation

> US National Institutes of Health, RePORTER application 10092015, MMRRC-UC Davis Research on Sex Influences of Genetic Variation Modeling in Female Mice (3U42OD012210-21S2). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10092015. Licensed CC0.

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