# Investigating Movement-evoked Pain in osteoArthritic Conditions (IMPACT): An Observational Study to Inform Culturally-Tailored Intervention Development

> **NIH NIH K23** · UNIVERSITY OF FLORIDA · 2021 · $126,440

## Abstract

Knee osteoarthritis (OA) is one the most problematic sources of persistent musculoskeletal pain, impaired
function and mobility, and reduced quality of life in older adults. Although these are common outcomes
associated with OA, they are disproportionately worse in older African Americans. These threats to healthy aging
demand further investigation into the most significant driver of OA pain and disability, which is movement. The
experience of pain due to movement, known as movement-evoked pain (MEP), often prohibits full participation
in daily living activities and self-management actions such as physical activity/exercise. MEP is consequently a
substantial contributor to high-impact chronic pain and disability in people with OA; yet, our understanding of the
mechanisms contributing to MEP and its management in older African Americans is severely limited. Therefore,
the overall goals for this two-phased Mentored Patient-Oriented Research Career Development Award (K23) is
to fill this knowledge gap by (1) characterizing the biopsychosocial-behavioral mechanisms of MEP and function
and (2) develop a mechanism-based self-management intervention (Pain Relief for OsteoArthritis using
Culturally-Tailored InterVentions for Black Elders [PROACTIVE]). This intervention will address the most pivotal
and culturally-relevant predictors of MEP and impaired function in older African Americans. Our methods
represent a new and substantive departure from current static pain assessments in chronic musculoskeletal
disorders by measuring pain with movement. This K23 proposes training and research activities that will launch
a program of research which advances the science of pain and disability in African American older adults. To
this end, I have assembled an interdisciplinary team of senior scientists representing nursing, psychology/pain
science, aging, and epidemiology/community engagement who will provide mentorship to help me achieve
proposed training goals and facilitate my transition to an independent research career. Primary training goals
essential to my research program include: (1) advance understanding of biopsychosocial and behavioral-
environmental mechanisms of OA pain, (2) develop a comprehensive knowledge base in the application of
community-engaged participatory research within experimental designs, and (3) enhance translational research
skills to function as an independent investigator capable of conducting rigorous clinical trials testing the
effectiveness of non-pharmacological, behavioral chronic pain self-management interventions within a cultured
community (e.g., southern African Americans). Phase 2 of the K23 will apply community-based participatory
mixed-methods to collaboratively create the PROACTIVE intervention. The University of Florida and University
of Connecticut are strong incubators for pain research and provide ideal environments to extend the PI’s prior
work and forge a path towards understanding multiple biopsychosocial and be...

## Key facts

- **NIH application ID:** 10092109
- **Project number:** 5K23AR076463-02
- **Recipient organization:** UNIVERSITY OF FLORIDA
- **Principal Investigator:** Staja Booker
- **Activity code:** K23 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $126,440
- **Award type:** 5
- **Project period:** 2020-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10092109

## Citation

> US National Institutes of Health, RePORTER application 10092109, Investigating Movement-evoked Pain in osteoArthritic Conditions (IMPACT): An Observational Study to Inform Culturally-Tailored Intervention Development (5K23AR076463-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10092109. Licensed CC0.

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