# Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical Sequelae

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2021 · $716,902

## Abstract

Abstract
Magnetic resonance imaging (MRI) is a proven technique that can non-invasively identify key pathological
features of carotid atherosclerosis. Prior MRI studies have shown that carotid intraplaque hemorrhage (IPH)
and lumen surface disruption are associated with increased risk for future ischemic events, and that IPH is
associated with more rapid plaque progression and presence of greater inflammatory activity and
neovascularization.
In our current cohort study, we tested the hypothesis that despite statin therapy and aggressive regulation of
blood pressure, stability of carotid lesions with IPH is compromised. Findings to date support our original
hypothesis. Further, preliminary interim analysis of our data suggest potential risk factors and MRI signal
characteristics that are associated with the progression of IPH. However, longer-term follow-up is critical to
confirm these promising initial findings.
The central hypotheses of this competing renewal are that i) hemodynamic factors and increased plaque
neovascularization are associated with the development of new or repeated IPH, and ii) the rate of plaque
progression is driven by repeated IPH that can be characterized by MR T1 and T2 mapping -- a quantitative
means to assess IPH resolution and recurrence.
The long-term goals of our research is to utilize MRI in prospective clinical studies to gain insight into the
pathogenesis of the high-risk carotid plaque, to identify risk factors associated with more rapid progression,
and ultimately, to establish carotid plaque imaging as a clinical diagnostic tool for reduction of incident stroke.
Globally, stroke remains one of the leading causes of serious long-term disability and mortality and carotid
atherosclerosis is a significant contributor. A better understanding of its pathogenesis is critically needed to
develop more effective methods for primary and secondary stroke prevention.

## Key facts

- **NIH application ID:** 10092205
- **Project number:** 5R01HL103609-09
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** THOMAS HATSUKAMI
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $716,902
- **Award type:** 5
- **Project period:** 2011-07-25 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10092205

## Citation

> US National Institutes of Health, RePORTER application 10092205, Carotid Intraplaque Hemorrhage: MRI of Therapeutic Response and Clinical Sequelae (5R01HL103609-09). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10092205. Licensed CC0.

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