# Protocol Review and Monitoring System

> **NIH NIH P30** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2021 · $60,973

## Abstract

PROTOCOL REVIEW AND MONITORING SYSTEM 
Project Summary 
The goal of the Protocol Review and Monitoring System (PRMS) at the Wake Forest Baptist Comprehensive 
Cancer Center (WFBCCC) is to provide systematic internal review and oversight of all cancer-related studies 
without duplicating traditional peer review. The Specific Aims of the PRMS are to 1) prioritizing all cancer 
clinical trials, regardless of source, proposed to be conducted at Wake Forest Baptist Medical Center; 2) 
reviewing the scientific merit of all investigator-initiated cancer clinical trials proposed to be conducted at Wake 
Forest Baptist Medical Center; and 3) conducting ongoing review of study accrual and scientific progress of 
WFBCCC clinical trials. The PRMS process is supported by Disease-Oriented Teams, the Operations Protocol 
Service, the Protocol Review Committee, and the Clinical Research Oversight Committee. Cancer-related 
protocols thus are initially developed by Disease-Oriented Team concept review, prioritized within the Disease- 
Oriented Team portfolio, and then reviewed by the Operations Protocol Service for logistical considerations 
and the Protocol Review Committee for scientific merit and final prioritization. Monitoring of accrual and 
scientific progress, including biostatistical reports and interim endpoint analyses, are carried out by the Clinical 
Research Oversight Committee, with Disease-Oriented Team support. In the most recent grant year, 111 trials 
were reviewed by the Protocol Review Committee and 280 trials were monitored by the Clinical Research 
Oversight Committee.

## Key facts

- **NIH application ID:** 10093000
- **Project number:** 5P30CA012197-46
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Bayard Powell
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $60,973
- **Award type:** 5
- **Project period:** 1997-02-01 → 2022-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10093000

## Citation

> US National Institutes of Health, RePORTER application 10093000, Protocol Review and Monitoring System (5P30CA012197-46). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10093000. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*