# The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve Health

> **NIH NIH UL1** · UNIVERSITY OF VIRGINIA · 2021 · $3,801,870

## Abstract

The integrated Translational Health Research Institute of Virginia (iTHRIV) program is a collaboration of
public and private institutions across the Commonwealth of Virginia that brings team science, innovation,
and a commitment to train the next generation of clinical and translational researchers. Our three iTHRIV
partners include University of Virginia (Central VA), Virginia Tech Carilion (Southwestern VA) and Inova
Health Systems (Northern VA). Our two iTHRIV affiliates are the Center for Open Science and the
Licensing and Ventures Group in Charlottesville. A particular strength of iTHRIV lies in integrating data
science approaches through all aspects of clinical translational research in order to speed discovery and
improve the health of our communities. iTHRIV has a central tenant that serves as the organizing
principle: health care solutions are hidden in underutilized data. Our overall goal is to deepen the iTHRIV
infrastructure to support clinical translational research to benefit the diverse rural and urban populations
that iTHRIV member clinicians serve. The unified approach across the components of this CTSA
application is to integrate data and data analytics to accelerate and streamline scientific workflows
for clinical trials, innovative therapeutic advancements, and the creation of more personalized
approaches to healthcare. Data science is a particular strength of our team and will allow us to
transform our cross-state informatics infrastructure by creating The Commons, a scalable research
hosting platform shared by iTHRIV partners that will serve as the foundation for our informatics support. It
will provide the infrastructure for the Research Concierge Services, the human and electronic approach
to supporting clinical translational research. This platform will combine data-centered approaches to
discovery by hosting and sharing datasets, applications, and other research objects with a human-centered
approach to design and systems architecture. The Commons is designed to serve both as a
technical framework and an approach to establishing processes and tools necessary to enable data
sharing between partner locations. The Concierge service informs and connects researchers to training,
support services and compliance resources to streamline the clinical translational research process. The
mission of iTHRIV, through the Commons and the Concierge Services, is to remove barriers to discovery
in Virginia and beyond. The iTHRIV Commons is conceptually similar to the NIH Data Commons, and the
implementation of this framework across partner sites will remove barriers to data access and other
research objects (algorithms, best practices, etc.), while enforcing compliance in the secure use of data.
iTHRIV will marry the expertise of our world class data science teams in The Commons to our
outstanding clinical translational researchers in order to uncover health care solutions.

## Key facts

- **NIH application ID:** 10094090
- **Project number:** 5UL1TR003015-03
- **Recipient organization:** UNIVERSITY OF VIRGINIA
- **Principal Investigator:** Donald E Brown
- **Activity code:** UL1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $3,801,870
- **Award type:** 5
- **Project period:** 2019-02-27 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10094090

## Citation

> US National Institutes of Health, RePORTER application 10094090, The integrated Translational Health Research Institute of Virginia (iTHRIV): Using Data to Improve Health (5UL1TR003015-03). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10094090. Licensed CC0.

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