# Animals and Instrumentation Core

> **NIH NIH P01** · AUGUSTA UNIVERSITY · 2021 · $293,394

## Abstract

ANIMALS AND INSTRUMENTATION CORE SUMMARY CB, BRANDS
The SHR experimental model of human essential hypertension is being used in Projects 1, 2, and 3 to study
the mechanisms for DAMP-induced hypertension and vascular and renal dysfunction. Accurate blood pressure
measurement is a requirement. The unique expertise of the Core B investigators adds a range of capabilities
that move the Animal Core well beyond a simple blood pressure-measuring service. Incorporating electrolyte
balance measurements adds depth and richness to interpreting blood pressure, through information such as
the pressure natriuresis relationship and transients in blood pressure and sodium excretion at initiation or
termination of treatment. Coupling chronic blood flow measurement with blood pressure reveals changes in
vascular resistance, which is the actual effector in the regulation of pressure and flow. Flexibility is important
because blood pressure will be measured over acute and chronic time frames, will be needed for very large
groups of animals, and may need to be accompanied by repeated arterial blood samples in the same animal
over a period of days to weeks. Core B is structured to provide the highest degree of quality control and
consistency in animal data used across all Projects.
 The overall goal of Core B is to provide the expertise, materials, and labor to measure and interpret
arterial pressure, blood flow, vascular resistance, renal function, and metabolic balance chronically in rats, and
to provide the platform for developing new approaches for delivery of experimental compounds or measuring
systemic or regional hemodynamics as needed. In addition, Core B will be positioned together with Core C to
effectively centralize and coordinate activities that are critical elements of several experiments. One key
mechanism for accomplishing this is through the Core B Hub Experiment in Aim 1. That experiment will provide
blood and tissue samples to all 3 Projects in coordination with Core C. The Hub Experiment was designed so
that Core B would serve as a hard link between the 3 Projects: The chronic blood pressure data and tissue
samples will be used by all Projects. A key feature of this approach is that these basic data used by all the
projects will come from the exact same animals. In addition to the direct benefits on data collection, analysis,
and interpretation, this function of Core B inherently facilitates networking and exchange of ideas and
information between all components of the Program Project, over and above what they already are doing
directly between projects. Thus, through this experiment and other activities, Core B as a whole indeed serves
as a hub that is critical to all 3 "spokes" (Projects) in this PPG.

## Key facts

- **NIH application ID:** 10094226
- **Project number:** 5P01HL134604-05
- **Recipient organization:** AUGUSTA UNIVERSITY
- **Principal Investigator:** Michael W. Brands
- **Activity code:** P01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $293,394
- **Award type:** 5
- **Project period:** 2017-02-01 → 2023-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10094226

## Citation

> US National Institutes of Health, RePORTER application 10094226, Animals and Instrumentation Core (5P01HL134604-05). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10094226. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*