# Metabolomics Evaluation of the Etiology of Pneumonia

> **NIH NIH K01** · UNIVERSITY OF COLORADO DENVER · 2021 · $128,250

## Abstract

Project Summary
Lilliam Ambroggio, PhD, MPH is an infectious diseases epidemiologist whose overarching career goal is to
improve outcomes for children with common, serious infections by developing methods to improve diagnostic
accuracy and implementing these methods into clinical practice. The research she proposes entitled
Metabolomic Evaluation in the Etiology of Pneumonia (MEEP) combines advanced statistical techniques with
1H-Nuclear Magnetic Resonance (NMR) metabolomics methodology to identify metabolites, which will facilitate
etiologic diagnosis of community-acquired pneumonia (CAP) in children. Such pathogen identification will result
in timely and accurate diagnosis that will permit targeted and effective management of this disease.
Candidate: Dr. Ambroggio is an Assistant Professor of Pediatrics with a joint appointment in the Divisions of
Hospital Medicine and Biostatistics and Epidemiology at Cincinnati Children's Hospital Medical Center
(CCHMC). She completed a Master's in Public Health and a Ph.D. in Epidemiology at Drexel University prior to
beginning a post-doctoral fellowship at CCHMC. Her previous work in the clinical management of CAP focusing
on antibiotic prescribing and diagnostic tools to detect pneumonia in combination with her previous training in
molecular and cellular biology have prepared her to conduct the proposed research. The proposed career
development plan will build upon her previous training with four training goals to enhance her trajectory toward
becoming an independent investigator: 1) Experiential and didactic learning in study design and execution of
quantitative 1H-NMR metabolomics; 2) Acquire and apply advanced statistical analyses; 3) Interpret
metabolomics data and its biological context and 4) Develop leadership and professional skills to execute
multicenter studies. Dr. Ambroggio proposes training activities that include didactic and experiential learning to
enable her to gain the necessary skills for metabolomic research.
Mentors/Environment: Dr. Ambroggio and her primary mentor, Samir S. Shah, MD, MSCE, have assembled a
strong team of co-mentors and advisors to guide Dr. Ambroggio through the proposed training and research
activities. The proposed career development plan utilizes the intellectual and metabolomics resources available
through the University of Cincinnati and CCHMC, as well as resources available at the University of Michigan
through Dr. Ambroggio's external mentor, Kathleen Stringer, PharmD. In addition Dr. Ambroggio will attend
national seminars and workshops when optimal training is not available locally. As an institution CCHMC is
committed to supporting junior faculty members through internal grants, administrative support and structured
opportunities for faculty networking and education. Dr. Ambroggio will be obtaining biological specimens for this
proposal from a fully operational, externally-funded prospective cohort study, CARPE DIEM. Both the ED and
inpatient services at CCH...

## Key facts

- **NIH application ID:** 10097962
- **Project number:** 5K01AI125413-06
- **Recipient organization:** UNIVERSITY OF COLORADO DENVER
- **Principal Investigator:** Lilliam Ambroggio
- **Activity code:** K01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $128,250
- **Award type:** 5
- **Project period:** 2017-03-07 → 2024-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10097962

## Citation

> US National Institutes of Health, RePORTER application 10097962, Metabolomics Evaluation of the Etiology of Pneumonia (5K01AI125413-06). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10097962. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*