# Function of RUNX1 in diverse Down syndrome tissues

> **NIH NIH R01** · UNIVERSITY OF COLORADO · 2021 · $1,890,079

## Abstract

Summary
 We seek to decipher the contribution of RUNX1 to the phenotypes seen in individuals with Down
syndrome. RUNX1 is a chromosome 21 encoded transcription factor involved in blood differentiation, a
process known to be altered in individuals with Down syndrome. Since transcription factors bind to DNA and
alter RNA polymerase activity we will determine if those two functions of RUNX1 are altered in individuals
with Down syndrome. We will also determine if drugs that increase or inhibit RUNX1 function behave
differently in cells with an extra copy of chromosome 21. Finally, we will determine how much of the altered
blood differentiation seen in Down syndrome is caused by RUNX1 by dosage normalizing RUNX1 in a
trisomy background (e.g.two copies in a trisomy cell line). We will then differentiation of iPSCs into embryoid
bodies and blood cells. Collectively this work will shed insights into the functions of RUNX1 and how it is
altered in Trisomy 21.

## Key facts

- **NIH application ID:** 10099762
- **Project number:** 1R01HL156475-01
- **Recipient organization:** UNIVERSITY OF COLORADO
- **Principal Investigator:** Mary A Allen
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $1,890,079
- **Award type:** 1
- **Project period:** 2021-02-01 → 2026-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10099762

## Citation

> US National Institutes of Health, RePORTER application 10099762, Function of RUNX1 in diverse Down syndrome tissues (1R01HL156475-01). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10099762. Licensed CC0.

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