# Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $594,720

## Abstract

Abstract
Radiotherapy is used to treat 60% of the cancer patients and 40% of curative cases. However, normal tissue
toxicities still prevent radiotherapy from achieving more effective tumor control in many patients despite decades
of technological development in intensity-modulated radiation therapy and image-guided radiation therapy. Ultra-
high dose rate, a.k.a., FLASH radiotherapy has recently re-emerged as a potential method to significantly
improve the radiation biological dose conformality on top of the physical dose conformality. Although existing X-
ray linac and proton systems can be modified to deliver the FLASH dose rate, they are limited in either field size,
depth penetration, or dose conformality to be useful for treating most human tumors. Conceptual systems such
as very high energy electron and PHASER will need to overcome significant and risky technological barriers to
be clinically practical. In this Academic-Industrial Partnerships project, we propose to develop a high dose rate
X-ray radiotherapy system that is a scale-up of existing technologies for clinical FLASH radiotherapy. There are
three major technical challenges in achieving the FLASH dose rate with X-rays. The first is the linear accelerator
that is capable to produce such a high dose rate. For this challenge, we hypothesize that a 12 MV X-ray
beam >300 Gy/s uncollimated dose rate can be achieved using a combination of already-demonstrated
accelerator technologies. The second challenge is the well-separated beam angles for good X-ray dosimetry.
The third challenge is intensity modulation for conformal dose distribution. The tightly correlated second and third
challenges are due to the slow mechanical movement of the common C-arm gantry and the MLC leaf speed. To
overcome these two challenges, we propose to develop a rotational ring-gantry FLASH IMRT platform with many
quasi-static MLCs. The fast-spinning ring-gantry system would deliver the entire treatment in an arc within a very
short time. The intensity modulation is achieved by using a decoupled MLC ring with a large number of MLC
banks each pre-shaping the aperture for rotational IMRT. The system would then be able to achieve highly
conformal dose distribution comparable to state of the art VMAT, and at the same time take advantage of the
FLASH radiobiology. We propose the following aims: Aim 1. High dose rate linac development; Aim 2.
Development of ROtational direct Aperture optimization with a Decoupled (ROAD) MLC ring; Aim 3.
Demonstration of rotational FLASH using a benchtop system.

## Key facts

- **NIH application ID:** 10101259
- **Project number:** 1R01CA255432-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** Salime Boucher
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $594,720
- **Award type:** 1
- **Project period:** 2021-03-15 → 2026-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10101259

## Citation

> US National Institutes of Health, RePORTER application 10101259, Development of an ultra-high dose rate rotational linac for FLASH Radiotherapy (1R01CA255432-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10101259. Licensed CC0.

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