# Studying Dynamics of Monocyte HIV RNA Persistence and the Interface with CNS Outcomes during Acute HIV Infection

> **NIH NIH F31** · UNIVERSITY OF HAWAII AT MANOA · 2020 · $29,520

## Abstract

The goal of my work is to elucidate the role of latent HIV infection in myeloid cells as an
approach to better understand myeloid immune dysfunction, inflammation and early stages of
cognitive decline during acute HIV infection (AHI). Our preliminary data show monocyte
associated HIV DNA data are consistent with the hypothesis that monocytes harbor HIV DNA
and RNA during early infection. Expanding on our on-going studies evaluating monocyte
associated HIV DNA, I intend to investigate monocyte HIV RNA burden in blood and CSF prior
to and post-ART intervention and in the context of adjunctive anti-inflammatory therapy during
AHI. The RV408/SEARCH018 cohort provides access to conducting my proposed single cell
assessments for monocyte phenotype and single cell RNA sequencing. Results from my aims
will form the basis for defining early HIV RNA transcriptional activity to our presently limited
understanding of monocyte associated HIV RNA burden.

## Key facts

- **NIH application ID:** 10101478
- **Project number:** 5F31AI145627-02
- **Recipient organization:** UNIVERSITY OF HAWAII AT MANOA
- **Principal Investigator:** ELIZABETH IRENE LAWS
- **Activity code:** F31 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $29,520
- **Award type:** 5
- **Project period:** 2019-09-01 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10101478

## Citation

> US National Institutes of Health, RePORTER application 10101478, Studying Dynamics of Monocyte HIV RNA Persistence and the Interface with CNS Outcomes during Acute HIV Infection (5F31AI145627-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10101478. Licensed CC0.

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