# MHC Genetic Typing Core

> **NIH NIH U42** · UNIVERSITY OF CALIFORNIA AT DAVIS · 2021 · $75,003

## Abstract

Abstract
The objectives of Specific Aim #3 will be to continue with genotyping for STRs and MHC class I
alleles, and facilitate the transition to the SNP panel developed by the Genetics and Genomics
Working Group (GGWG) of the NPCR Consortium. An STR panel that was designed for genetic
management will be used for parentage assessment and estimating the population genetic metrics
of the SPF animals. Genotyping based on this panel of STRs will be conducted at the Veterinary
Genetics Laboratory (VGL) where these analyses are already being performed on a routine basis.
The genetic information from this panel of markers will be used to develop multigenerational
pedigrees and also maintain the SPF colony genetic diversity. Determination of MHC Class I types
will also be performed at the VGL based on a panel of MHC-linked STRs. This, in combination with
segregation analysis in animals with known pedigrees, will allow the establishment zygosity status
of Class I types and of defined haplotypes spanning the MHC region of rhesus macaques. The work
delineated in Aim #3 continues an existing process that has addressed the needs of the CNPRC for
genetic characterization and management of animals in the SPF program and the rhesus colony at
large. It expands into the implementation of state-of-the-art technology for transitioning into the
routine use of SNP technology as the genotyping method of choice. The combined expertise in
virology and genetics at CNPRC and of our collaborators provide the ideal intellectual resources for
the establishment of an SPF breeding colony that is genetically characterized and MHC-defined.

## Key facts

- **NIH application ID:** 10101713
- **Project number:** 5U42OD010990-21
- **Recipient organization:** UNIVERSITY OF CALIFORNIA AT DAVIS
- **Principal Investigator:** Maria Cecilia Torres Penedo
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $75,003
- **Award type:** 5
- **Project period:** 2000-09-30 → 2024-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10101713

## Citation

> US National Institutes of Health, RePORTER application 10101713, MHC Genetic Typing Core (5U42OD010990-21). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10101713. Licensed CC0.

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