# The experience of human subjects with brain organoid research

> **NIH NIH K99** · UNIVERSITY OF WASHINGTON · 2020 · $132,759

## Abstract

PROJECT SUMMARY
Efforts to understand the mechanisms of brain-based disease have been hindered by the limited
ability of animal models to reflect the full complexity of human brain and behavior. Brain organoids
represent a potential solution, allowing scientists to model human neurodevelopmental and
disease processes in-vitro. These multicellular, three-dimensional tissue structures are derived
from induced pluripotent stem cells and self-organize to recapitulate aspects of human cortical
development. Brain organoids are linked to their original human donor through shared DNA, and
also through what they can reveal about individual-specific patterns of brain development and
dysfunction. Given the central role the brain plays in personal identity, it is critical to understand
what human donors think and feel about brain organoids grown from their cells, and consider
whether organoid models of the brain deserve unique moral status compared to, for example,
lung or kidney organoids. The proposed research seeks to engage participants and other
stakeholders to explore ethical issues in brain organoid research, and thus addresses a core
principle of BRAIN Initiative: considering the ethical implications of neuroscience research. In Aim
1, qualitative interviews with current participants will be conducted to explore their perspectives
towards brain organoid research including beliefs about meaning, moral status, and permissible
uses of organoid tissue. In Aim 2, an educational video that describes brain organoids will be
imbedded into an online survey and used to measure attitudes in larger groups of stakeholders
who represent future participants in brain organoid research. In Aim 3, insights learned from
participants and stakeholders about preferences for brain organoid research will be compared to
current research practices and modifications to guide the field going forward will be proposed.
The long-term goal is to ensure that brain organoid research can achieve its scientific potential
and proceed in accordance with donor beliefs and values. The proposed research and training
plan will leverage expertise of an interdisciplinary team of mentors and strong
bioethics/neuroethics research environment across the University of Washington Center for
Neurotechnology and the Treuman Katz Center for Pediatric Bioethics at Seattle Children’s.
During the mentored phase of the award, the applicant will gain new content knowledge in the
basic science of brain organoids, learn new skills for neuroscience communication, and complete
a master’s degree in bioethics. This additional training will equip the applicant with the skills
necessary to conduct the proposed research and transition into an independent faculty position.

## Key facts

- **NIH application ID:** 10101989
- **Project number:** 1K99MH125328-01
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Kate E. MacDuffie
- **Activity code:** K99 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $132,759
- **Award type:** 1
- **Project period:** 2020-09-11 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10101989

## Citation

> US National Institutes of Health, RePORTER application 10101989, The experience of human subjects with brain organoid research (1K99MH125328-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10101989. Licensed CC0.

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