# NCTN - Network Lead Academic Participating Site: USC

> **NIH NIH UG1** · UNIVERSITY OF SOUTHERN CALIFORNIA · 2021 · $409,376

## Abstract

ABSTRACT
The USC Norris Comprehensive Cancer Center first participated in the research activities of
SWOG in 1987 and was initially funded in 1992. This five-year grant cycle has had increased
administrative and academic participation, with maintenance of high clinical and correlative trial
entry, commensurate with available SWOG funding and added resources from USC. The major
emphases of the USC team are (a) to provide leadership across the NTCN to design and
efficiently perform clinical trials evaluating the safety and efficacy of novel regimens or
modifications of existing regimens; (b) to provide leadership in biomarker development and in
integration of new technologies into NCTN trials, taking advantage of a systematic approach to
collection, processing, and storage of blood, normal tissue, fresh or frozen tumor tissue, and other
relevant biologic samples for molecular and pharmacologic studies; and (c) to evaluate cancer
treatment regimens in special patient populations, such as rare cancers, the elderly and ethnic
minorities. USC investigators have not only contributed extensively to SWOG trials but have
demonstrated administrative/academic leadership, facilitating the translation of specific themes
of investigation to SWOG. Recent NCTN trials such as SWOG/ALLIANCE 80405 and S1401
characterizing metastatic colorectal and prostate cancer has significant increased the
understanding of molecular subtyping and characterization of both cancers integrating cutting
edge technologies including NGS testing and single cell molecular classification. USC UG1
members are playing an active role in NCI task forces and steering committees. As part of its
dedication to cancer clinical research, USC has been successful in mentoring young investigators
through the UM1 Career Development Awards, Project Team Memberships and SWOG Young
Investigator Awards. USC has expanded its institutional training and mentoring capabilities.
Lastly, as a Network Lead Academic Participating Site, USC will continue to bring unique
strengths to the NCI National Clinical Trials Network thanks to its strength in recruitment of
minorities to clinical trials, accrual to rare cancers such as biliary and bladder cancers, and a well-
developed clinical research infrastructure.

## Key facts

- **NIH application ID:** 10102208
- **Project number:** 5UG1CA180830-08
- **Recipient organization:** UNIVERSITY OF SOUTHERN CALIFORNIA
- **Principal Investigator:** Anthony Boutros El-Khoueiry
- **Activity code:** UG1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $409,376
- **Award type:** 5
- **Project period:** 2014-04-17 → 2025-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10102208

## Citation

> US National Institutes of Health, RePORTER application 10102208, NCTN - Network Lead Academic Participating Site: USC (5UG1CA180830-08). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10102208. Licensed CC0.

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