# Mentoring Patient-Oriented Research to Promote ARDS Precision Medicine

> **NIH NIH K24** · UNIVERSITY OF PENNSYLVANIA · 2021 · $124,478

## Abstract

Acute respiratory distress syndrome (ARDS) afflicts up to 25% of mechanically ventilated patients admitted to
an intensive care unit, carries a mortality that exceeds 30%, and has no approved pharmacologic therapy.
Patient-oriented research (POR) to identify ARDS molecular subphenotypes that may respond to precision
therapy is thus critically important. Dr. Meyer’s research career has been devoted to identifying genetic and
molecular risk factors that account for individual variation in ARDS risk, and harnessing this information to
uncover novel treatment paradigms for ARDS. The goal of this application is to train a new generation of
scientists in translational POR that advances precision medicine for ARDS, by enhancing Dr. Meyer’s
mentorship capabilities and fostering new opportunities for research that integrates clinical informatics and
molecular informatics. Applying expanded genomic, bioinformatic, and epidemiologic tools, this application will
test whether a circulating immune profile associates with plasma protein-defined subphenotypes of sepsis-
associated ARDS, and whether integrating genetic, gene expression, cytometric, plasma protein, and clinical
data can identify reproducible patterns of host response during ARDS. The completion of these aims will
expand Dr. Meyer’s research program as a POR training resource in ARDS and will enhance her effectiveness
as a mentor with specific training activities for Dr. Meyer and her trainees.

## Key facts

- **NIH application ID:** 10104153
- **Project number:** 1K24HL155804-01
- **Recipient organization:** UNIVERSITY OF PENNSYLVANIA
- **Principal Investigator:** Nuala Jennings Meyer
- **Activity code:** K24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $124,478
- **Award type:** 1
- **Project period:** 2021-01-01 → 2021-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10104153

## Citation

> US National Institutes of Health, RePORTER application 10104153, Mentoring Patient-Oriented Research to Promote ARDS Precision Medicine (1K24HL155804-01). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10104153. Licensed CC0.

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