# Translating basic habituation research to childhood obesity treatment

> **NIH NIH R01** · UNIVERSITY OF TENNESSEE KNOXVILLE · 2021 · $562,363

## Abstract

PROJECT SUMMARY/ABSTRACT
Identifying successful methods for reducing long-term energy intake continues to be a challenge in obesity
treatment. Basic behavioral research has found that the rate of habituation (i.e., rate of reduction in
physiological and behavioral responding) to food is related to amount of food consumed, and faster habituation
rates reduce food intake. The rate of habituation to food can be accelerated when variety in foods is limited,
producing decreased intake. Thus, a dietary prescription that limits variety of high-energy-dense (RED) foods
may boost ability to reduce long-term energy intake, enhancing long-term weight loss. Furthermore, habituation
rates to food show large individual variability. Individuals with overweight habituate slower to food than
individuals with a healthy weight, and slower habituation rates predict greater increases in child standardized
body mass index. Thus, slower habituation rates to food may be a behavioral phenotype for increased risk of
suboptimal weight outcomes. Obesity interventions that accelerate habituation to food may then be more
beneficial for those with this behavioral phenotype. We have been conducting a line of translational research
that applies habituation theory to obesity treatment, involving: 1) studies systematically testing basic concepts
to better inform intervention development; 2) “proof-of-concept” testing; and 3) efficacy trials. The long-term
goal is to develop a dietary prescription that harnesses habituation as a mechanism for reducing long-term
energy intake. We have piloted a limited variety prescription (limited variety of RED foods) within a 6-month
family-based behavioral obesity treatment (FBT) for children. Twenty-four families, with a child > 85th percentile
body mass index (BMI) and aged 8 to 12 years, were randomized to FBT or to FBT that included a limited
dietary variety prescription (FBT+Variety). At 6-months children in FBT+Variety had a significantly greater
reduction in percent overweight than those in FBT (−15.4% vs.− 8.9%). Research is needed to examine if
limiting variety improves long-term weight loss, if this improvement is due to enhanced habituation, and explore
if there is a behavioral phenotype that more greatly benefits from this dietary approach. We plan to implement
a novel limited food variety prescription within a 24-month FBT to examine its effect on 24-month BMI. One
hundred fifty-six children aged 8 to 12 years at > 85th percentile BMI will be randomized to one of two, 24-
month interventions compared in our 6-month pilot study: FBT or FBT+Variety. Child and adult caregiver
assessments will occur at 0, 6, 12, 18, and 24 months on anthropometrics, dietary intake, and habituation. We
will determine: 1) the influence of FBT+Variety on long-term weight loss; and 2) the influence of FBT+Variety
on long-term habituation and if habituation rate mediates differences in dietary intake and BMI between
conditions. We will explore if the behavio...

## Key facts

- **NIH application ID:** 10104491
- **Project number:** 5R01DK121360-03
- **Recipient organization:** UNIVERSITY OF TENNESSEE KNOXVILLE
- **Principal Investigator:** Hollie A Raynor
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $562,363
- **Award type:** 5
- **Project period:** 2019-03-01 → 2024-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10104491

## Citation

> US National Institutes of Health, RePORTER application 10104491, Translating basic habituation research to childhood obesity treatment (5R01DK121360-03). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10104491. Licensed CC0.

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