# Childhood Liver Disease Research Network Data Coordinating Center

> **NIH NIH U24** · UNIVERSITY OF MICHIGAN AT ANN ARBOR · 2020 · $174,408

## Abstract

Project Summary Abstract
Chronic pediatric liver disease is a devastating group of conditions that have a profound effect on children,
their families, and our society. Biliary atresia and the other cholestatic liver diseases studied by this network
account for over half of liver transplants performed in children in the United States. A better understanding of
the diseases studied by this network will help provide better care of patients with chronic liver disease. The
gaps in our current knowledge regarding these diseases provide compelling scientific justification for the
continuation of the Childhood Liver Disease Research Network (ChiLDReN).
As stated in the RFA, the primary goal of this proposal is to continue clinical and translational research on rare
pediatric liver diseases that include: biliary atresia; Alagille syndrome; alpha-1-antitrypsin deficiency;
progressive familial intrahepatic cholestasis syndromes; bile acid synthesis defects; mitochondrial
hepatopathies; idiopathic neonatal hepatitis; cystic fibrosis liver disease; and primary sclerosing cholangitis. It
is anticipated that the network will consist of up to 13 clinical sites and a single scientific and data coordinating
center (SDCC). The SDCC for the ChiLDReN study is charged with providing coordination, communications
and logistical support, clinical study design, centralized data management, biosample management, quality
assurance, and analytical support to the research sites and the NIDDK Project Scientist for all ChiLDReN
studies. The proposing team is submitting this response to RFA-DK-18-502 to continue as the SDCC for the
network.

## Key facts

- **NIH application ID:** 10104765
- **Project number:** 3U24DK062456-18S3
- **Recipient organization:** UNIVERSITY OF MICHIGAN AT ANN ARBOR
- **Principal Investigator:** JOHN C MAGEE
- **Activity code:** U24 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $174,408
- **Award type:** 3
- **Project period:** 2020-05-01 → 2020-05-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10104765

## Citation

> US National Institutes of Health, RePORTER application 10104765, Childhood Liver Disease Research Network Data Coordinating Center (3U24DK062456-18S3). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10104765. Licensed CC0.

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