# Nonhuman Primate (NHP) Core B

> **NIH NIH U19** · OREGON HEALTH & SCIENCE UNIVERSITY · 2021 · $738,635

## Abstract

Core B (Nonhuman Primate) Summary
The Nonhuman Primate (NHP) Core seeks to consolidate supervision and performance of the NHP
experimental protocols assessing the immunogenicity, tropism, and efficacy of CMV/SIV vectors proposed as
part of the  Integrated Preclinical/Clinical AIDS Vaccine Development Program's (IPCAVD) “Development of
Immunogenicity- and Efficacy-Optimized CMV Vectors for an HIV/AIDS Vaccine” into a structured Core
composed of highly experienced research personnel. This Core will provide the expertise and technical support
required to insure successful completion of the multifaceted and extensive NHP research protocols supporting
the work proposed in Project 1 - “Immunogenicity, Efficacy and Immune Correlates Analysis of CMV Vectors
Modified to Differentially Elicit Unconventional CD8+ T Cell Responses in Rhesus Macaques”; Project 2 –
“Optimization of CMV Vector CD8+ T Cell Response Programming by Modification of Vector”; and Project 4 –
“Optimization of CMV Vector CD8+ T Cell Response Programming by Modification of CMV-Encoded Molecular
Mechanisms that Interfere with Unconventional CD8+ T Cell Response Priming”. The global objective of the
Core is to provide leadership and technical expertise to ensure consistency and quality control in animal
selection, execution of study protocols, application of experimental procedures, animal observations and data
collection necessary to meet the objectives of the IPCAVD Program's vector development and efficacy
assessment protocols. To accomplish this, the Core will manage and directly supervise all NHP studies for the
IPCAVD including: 1) animal selection; 2) animal housing and general husbandry; 3) experimental procedures
and clinical management; 4) specimen collection and processing; 5) necropsy studies; and 6) acquisition and
management of animal demographic, physiologic, clinical, and pathologic data.

## Key facts

- **NIH application ID:** 10105274
- **Project number:** 5U19AI128741-05
- **Recipient organization:** OREGON HEALTH & SCIENCE UNIVERSITY
- **Principal Investigator:** Michael K Axthelm
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $738,635
- **Award type:** 5
- **Project period:** 2017-03-02 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10105274

## Citation

> US National Institutes of Health, RePORTER application 10105274, Nonhuman Primate (NHP) Core B (5U19AI128741-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10105274. Licensed CC0.

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