# Continuation of the NuMoM2b Heart Health Study

> **NIH NIH U01** · RESEARCH TRIANGLE INSTITUTE · 2021 · $2,550,754

## Abstract

PROJECT SUMMARY/ABSTRACT
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity in U.S. women at all ages, and
large knowledge gaps exist in CVD predictive and preventive strategies for women. The nuMoM2b Heart
Health Study (nuMoM2b-HHS) has followed a demographically diverse cohort of 4,475 women enrolled and
richly phenotyped during their first pregnancy, with data and biospecimens prospectively collected for up to 7
years thereafter. The overarching scientific goal of the nuMoM2b-HHS is to define the relationship between
adverse pregnancy outcomes (APOs) and CVD to optimize CVD prediction, prevention, and treatment
strategies for women. Continued follow-up of this cohort, building on a foundation of existing high-quality
data, biospecimens, and administrative structures with a robust framework for ancillary study development
and implementation, provides a unique opportunity to address knowledge gaps regarding the early
mechanisms and trajectory of CVD in women. We propose to continue nuMoM2b-HHS follow-up through
semiannual contacts and an in-person visit to assess CVD risk factors during grant years 3-5 (Aim 1).
Accumulated longitudinal data and biospecimens will serve as a broadly accessible platform for ancillary
studies to identify early mechanisms of CVD and to address additional NIH priority domains including early
manifestations of cerebrovascular and renal disease in reproductive-age women. Ancillary studies (Aim 2)
will expand data collection during the follow-up contacts and in-person visit, and add to the planned contact
schedule, to permit the effective targeting of knowledge gaps required to optimize predictive and preventive
strategies. The Specific Aims reflect a multifaceted approach to the study of the incidence and mechanisms
of CVD development in women of reproductive age, focusing on the incidence of CVD risk factors in women
with and without APOs (Aim 3); the associations between atherogenic phenotypes and sleep-disordered
breathing during and after pregnancy and estimated CVD risk 6-15 years later (Aims 4 and 5, respectively);
and identification of modifiable factors that influence or moderate these associations (Aim 6).
This application has several strengths that reflect the potential for long-term success of the cohort: (1) The
nuMoM2b-HHS will be led by three deeply experienced PIs with complementary domains of expertise in
cardiology, maternal-fetal medicine, and biostatistics. (2) The network has robust infrastructure in place to
maintain long-term participant engagement and support rigorous data collection. (3) The cohort's high-quality
data and biospecimens have been collected under regulatory frameworks that support resource sharing and
use in future research. (4) The network has established processes for successfully proposing, reviewing, and
implementing ancillary studies. This foundation of strong leadership, robust administrative and operational
infrastructure, and actualized long-term vi...

## Key facts

- **NIH application ID:** 10105356
- **Project number:** 5U01HL145358-02
- **Recipient organization:** RESEARCH TRIANGLE INSTITUTE
- **Principal Investigator:** Philip Greenland
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $2,550,754
- **Award type:** 5
- **Project period:** 2020-02-15 → 2027-01-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10105356

## Citation

> US National Institutes of Health, RePORTER application 10105356, Continuation of the NuMoM2b Heart Health Study (5U01HL145358-02). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10105356. Licensed CC0.

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