Project Summary The overall goals of the Design and Analysis Core (DAC) are to provide clinical translational neuroscience- relevant design and analytic resources to enhance and support COBRE Center for Neuromodulation (CCN) projects, pilots and cores, and enhance the neuroscience research capacity at Butler Hospital specifically and in Rhode Island, generally. The DAC will focus on providing support in three research contexts: planning, support, and training. During planning stages, DAC will assist Project Leaders in crafting research design, research infrastructure and resource planning, and development of data analysis plans. The goal is to generate and support feasible designs that support and provide a mechanism to ensure and verify high quality data, and reproducible data analysis and sound statistical inference. The DAC will provide and coordinate access to and ensure responsible use of a computational support infrastructure at Butler Hospital that has been designed to facilitate reproducible data analysis in the clinical neurosciences. The DAC supports its educational mission by training PLs and their teams in application of computing tools and management of large and complex data. A unique focus of the DAC is in the planning and design of studies that facilitate clinical translational neuroscience research, meaning: we assist PLs in planning and analysis of complex and high dimensional neuroscience data together with clinical (e.g., behavioral) data in order to speed translation of results and more effectively communicate the clinical importance of the findings. Our long-term goal is to grow into a resource that serves the neuroscientists, psychologists and clinicians at Butler Hospital by providing a broad range of statistical and high-performance computing services. To support the CCN in achieving its mission, the DAC has the following specific aims: Aim 1) Support CNN project leaders in the design and analysis;; Aim 2) Enhance and refine existing computing infrastructure;; Aim 3) Enhance clinical neuroscience research in the Rhode Island community.