# Mechanisms underlying atrial fibrillation associated with chronic kidney disease

> **NIH NIH R01** · BAYLOR COLLEGE OF MEDICINE · 2021 · $510,632

## Abstract

PROJECT SUMMARY / ABSTRACT
Chronic kidney disease (CKD) is a known predictor of cardiovascular morbidity and mortality, and is an
important risk factor for atrial fibrillation (AF). Very little remains known about the molecular mechanisms
underlying AF associated with CKD. Our preliminary data reveal activation of the NLRP3 inflammasome within
atrial myocytes isolated in a mouse model of CKD. The long-term goal of this project is to elucidate the
molecular and cellular mechanisms underlying AF development as a result of inflammasome activation in mice
with CKD. We will test the hypothesis that enhanced activation of the NLRP3 inflammasome within atrial
myocytes enhances the susceptibility to AF by promoting proarrhythmogenic Ca2+ releases via increased
SPEG-phosphorylation of RyR2.

## Key facts

- **NIH application ID:** 10106664
- **Project number:** 5R01HL147108-03
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Na Li
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $510,632
- **Award type:** 5
- **Project period:** 2019-04-15 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10106664

## Citation

> US National Institutes of Health, RePORTER application 10106664, Mechanisms underlying atrial fibrillation associated with chronic kidney disease (5R01HL147108-03). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10106664. Licensed CC0.

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