# Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin

> **NIH NIH N01** · UNIVERSITY OF MINNESOTA · 2020 · $642,574

## Abstract

The Multi-Ethnic Study of Atherosclerosis (MESA) is a study of the correlates, predictors, and progression of
subclinical cardiovascular disease (CVD) in a diverse population-based sample of men and women aged 45-84
who had no evidence of clinical CVD at baseline. During the initial funding period of MESA, 6,814 participants
were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary
atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery
dilation, radial artery tonometry, ankle-brachial index measurement, and retinal photography. A number of
other variables including abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional
myocardial function; established and putative laboratory risk markers; socioeconomic, psychological,
behavioral and environmental characteristics; and genetic variants were assessed in subsets of the MESA
cohort. Examinations of selected components were repeated over five subsequent examinations spanning
approximately 16 years and the cohort has been continuously followed for clinical CVD events since the
baseline examination.
The study will continue to support in-depth ancillary studies that are funded outside of the NHLBI contract.
These studies will be operationally integrated into the main study, and the data will be shared across the entire
“MESA Suite” of studies, per current MESA and NIH data-sharing policies. The study’s data will be provided to
interested investigators through a defined process that encourages maximum data utilization while protecting
participant confidentiality.

## Key facts

- **NIH application ID:** 10106963
- **Project number:** 75N92020D00006-0-759202000001-1
- **Recipient organization:** UNIVERSITY OF MINNESOTA
- **Principal Investigator:** James  Pankow
- **Activity code:** N01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $642,574
- **Award type:** —
- **Project period:** 2019-12-19 → 2024-12-18

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10106963

## Citation

> US National Institutes of Health, RePORTER application 10106963, Task Area A shall encompass annual follow-up of cohort members, clinical events investigations, study operations, and data analysis and manuscript writing. If implemented, Task A.1 will provide fundin (75N92020D00006-0-759202000001-1). Retrieved via AI Analytics 2026-06-14 from https://api.ai-analytics.org/grant/nih/10106963. Licensed CC0.

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