# Cell-Type Specific Regulation of Dendritic mRNA in the Hippocampus

> **NIH NIH R00** · VIRGINIA POLYTECHNIC INST AND ST UNIV · 2020 · $15,749

## Abstract

PROJECT SUMMARY
The overall goal of this career development award is to acquire the essential research and professional skills
needed to establish an extramurally funded research group to investigate the post-transcription mechanisms
underlying social memory. Specifically, the grant builds upon previous training in the field of mRNA regulation
in neuronal dendrites and adds training in essential and innovative techniques, such as bioinformatics analyses
and ribosome profiling, to further pursue genome-wide translational regulation in neuronal cell-types important
for social memory. The grant brings together a number of local experts to synergistically support both the
career and research training. Formal training in next generation sequencing analyses will be acquired through
didactic coursework and hands-on instruction at the primary institution. Training in translational profiling
methods and analyses will be taught under the guidance of a co-mentor at a local top university. Laboratory
management, grantsmanship and scientific communication skills will be attained through workshops, short
courses and presentations at national and regional scientific meetings, respectively. Lastly, mentorship skills
will be honed through a summer student research program at the primary institution. Upon successful
completion of the training portion of the grant, it is expected that the awardee will be highly competitive for a
tenure-track faculty position at research-intensive university.
During the independent phase of the award, the research plan expands to include a genetic targeting approach
to interrogate how mRNA stability in specific cell-types contributes to synaptic and behavioral plasticity
underlying social learning. Work from this grant will expand our knowledge of the post-transcriptional
mechanisms regulating translation in neurons and potentially identify novel therapeutic candidates for the
treatment of neuropsychiatric disorders with abnormal sociocognitive processing, such as autism spectrum
disorders and schizophrenia.

## Key facts

- **NIH application ID:** 10107497
- **Project number:** 3R00MH109626-03S1
- **Recipient organization:** VIRGINIA POLYTECHNIC INST AND ST UNIV
- **Principal Investigator:** Shannon Farris
- **Activity code:** R00 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $15,749
- **Award type:** 3
- **Project period:** 2018-11-01 → 2021-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10107497

## Citation

> US National Institutes of Health, RePORTER application 10107497, Cell-Type Specific Regulation of Dendritic mRNA in the Hippocampus (3R00MH109626-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10107497. Licensed CC0.

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