# Neurobiology of the Bronchopulmonary System

> **NIH NIH R35** · JOHNS HOPKINS UNIVERSITY · 2021 · $938,076

## Abstract

Project Summary/ Abstract
Basic and clinical research over the past decade is shedding new light on the major role played
by the nervous system in respiratory pathophysiology, in particular in the “hypertussivity”
associated with chronic unproductive cough, in the “airways hyperresponsiveness””
associated with of asthma, and in the airway narrowing and secretions associated with
COPD. The evidence supports the hypothesis that these hyperactive disorders are in part
secondary to dysregulation of vagal afferent C-fibers that comprise some 75% of the nerves
within the respiratory tract. This grant aims to advance our understanding of the nature of the
inflammatory mediators (autacoids and cytokines) responsible for activating airway C-fibers and
the specific ionic mechanisms underlying this activity. This R35 will replace my two active R01
grants: R01 HL137807 “Mechanisms of Inflammatory Activation of Vagal C-Fibers in the
Respiratory Tract” and R01HL122228 “Control of Airway Sensory Nerve Function by Voltage-
Gated Sodium Channel Subtypes.” The R35 funding will allow us to go beyond the aims of the
R01 grants that focus on healthy animals, and delve into the mechanisms that lead to the
neuroplasticity associated with airway inflammation. In particular, we propose to evaluate the
neuroplasticity in the afferent nervous system that accompanies viral infection during early life
“critical periods” with the hypothesis that such infections cause persistent neuroplastic changes.
These changes lead to a hyperreactive neurophysiological state that can last into adulthood.
This grant will also allow us to continue to advance more user-friendly technologies for studying
airway nerves by taking advantage of modern imaging methodologies. These methods will not
only serve to advance our own studies, they will also likely be exported to other laboratories
interested in visceral neuroscience in general, and airway neuroscience in particular. We will
also continue to advance our techniques and studies into the study of human bronchial
innervation. Finally, the award will help keep the path paved for continued mentoring of young
investigators interested in pursuing airway neuroscience research.

## Key facts

- **NIH application ID:** 10108520
- **Project number:** 1R35HL155671-01
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Bradley Joel Undem
- **Activity code:** R35 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $938,076
- **Award type:** 1
- **Project period:** 2021-03-01 → 2028-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10108520

## Citation

> US National Institutes of Health, RePORTER application 10108520, Neurobiology of the Bronchopulmonary System (1R35HL155671-01). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10108520. Licensed CC0.

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