# Determining the Mechanism for ApoC-III Stimulation of IL-10 and Tregs in the Intestine: Is this Novel Effect Beneficial?

> **NIH NIH R03** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $117,375

## Abstract

Kohan R03: Determining the mechanism for apoC-III stimulation of IL-10 and Tregs in the intestine: is
this novel effect beneficial?
Project Summary:
Since the intestinal lymphatics are responsible for dietary fat transport and also serve as a main route for
transport of antigens and antigen-presenting cells to the mesenteric lymph nodes, we hypothesized that
intestinal apoC-III may also influence the intestinal immune system through its inhibition of dietary fat
absorption. These studies will yield critical mechanistic information about the role of apoC-III in modulating T
cells, and how this mediator of intestinal lipid absorption influences intestinal inflammatory disease. We will use
T cell culture models, as well as in vivo studies in apoC-III transgenic mice, to determine how apoC-III alters T
cell homeostasis and intestinal inflammation. Finally, due to the excitement about apoC-III in the
cardiovascular field and as a pharmaceutical target, it is critical for us to determine how apoC-III is regulating
the immune system.

## Key facts

- **NIH application ID:** 10110204
- **Project number:** 7R03DK116011-02
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Alison Bloom Kohan
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $117,375
- **Award type:** 7
- **Project period:** 2019-04-17 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10110204

## Citation

> US National Institutes of Health, RePORTER application 10110204, Determining the Mechanism for ApoC-III Stimulation of IL-10 and Tregs in the Intestine: Is this Novel Effect Beneficial? (7R03DK116011-02). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10110204. Licensed CC0.

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