# Regulation of c-myc translation by hnRNP A1: Role in multiple myeloma tumor responses

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA LOS ANGELES · 2021 · $288,225

## Abstract

The main objective of this project is to provide a rationale for future therapeutic targeting of the c-myc IRES
which mediates cap-independent translation in multiple myeloma cells. IRES-dependent myc translation is
critical for tumor cell survival during ER stress in this tumor model. The aims include studying the mechanism
by which the MNK kinase, the hnRNP A1 ITAF and the ribosomal protein RPS25 mediate IRES function; the
mechanism and importance of myc inducing A1 and RPS25 expression and the potential for an inhibitor of
IRES function in myeloma. The viability versus death of myeloma cells as well as their ability to achieve c-myc
translation and IRES activity in vitro will be studied. In addition, a murine model of c-myc-driven myeloma will
be exploited to determine the in vivo roles of hnRNPA1 and IRES activity in tumor progression as well as the
potential efficacy of our IRES inhibitors.

## Key facts

- **NIH application ID:** 10111470
- **Project number:** 5R01CA214246-05
- **Recipient organization:** UNIVERSITY OF CALIFORNIA LOS ANGELES
- **Principal Investigator:** ALAN K LICHTENSTEIN
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $288,225
- **Award type:** 5
- **Project period:** 2017-03-17 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10111470

## Citation

> US National Institutes of Health, RePORTER application 10111470, Regulation of c-myc translation by hnRNP A1: Role in multiple myeloma tumor responses (5R01CA214246-05). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10111470. Licensed CC0.

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