# Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study

> **NIH NIH R01** · WAKE FOREST UNIVERSITY HEALTH SCIENCES · 2020 · $1,979,793

## Abstract

ABSTRACT
The SEARCH for Diabetes in Youth Study (SEARCH) is a longitudinal cohort study of youth-onset diabetes,
enrolling incident cohorts from 2002 through 2018 and collecting data to characterize disease-associated burden.
A rich wealth of data have been collected, including data generated through clinic-based assessments,
biomarker assays, questionnaires, and medical record abstraction. Administered across five clinical sites, data
collected through SEARCH represent a highly diverse population of youth with diabetes, with oversampling of
racial and ethnic minority populations in the most recent funding cycle. Centralized support for the administration
of SEARCH, including management of data and conduct of study analyses, is performed by the SEARCH
Biostatistics Research Center (BRC) at Wake Forest School of Medicine. The SEARCH study has been
supported through four funding cycles, with the most recent funding cycle ending on May 31, 2020. Data
collected includes neurocognitive and echocardiography collected for the first time in this most recent funding
cycle and repeat assessments for the characterization of retinopathy, diabetic neuropathy, diabetes-associated
kidney disease and arterial stiffness. This longitudinal data allows for an assessment of change across time and
identification of protective or risk factors associated with development of or worsening of disease-associated
complications. Finally, during this most recent funding cycle, omics-based assessments were added, including
genotyping and, through an ancillary study supported by the Children’s Health Exposure Assessment Resource
(CHEAR), an untargeted metabolomics assessment. This proposal is in response to RFA-DK-14-508 to sustain
the SEARCH BRC infrastructure necessary to analyze data and disseminate results to the scientific community
through publications and presentations, focusing on contemporary questions relevant to enhancing our
understanding of the social, environmental and biological determinants of youth-onset diabetes complications
and progression. To that end, the BRC will 1) develop, maintain and prioritize a list of potential scientific
manuscripts following established SEARCH Study procedures, 2) provide support in statistical analyses and
interpretation of all SEARCH data, 3) collaborate with the SEARCH sites to support the dissemination of key
scientific information derived from the study through presentations at scientific meetings and in scholarly, peer-
reviewed journals, 4) provide oversight of the study’s Central Biosample Repository and 5) oversee transfer of
any remaining biosamples and data to NIDDK biosample and data repositories.

## Key facts

- **NIH application ID:** 10111923
- **Project number:** 1R01DK127208-01
- **Recipient organization:** WAKE FOREST UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Ralph B. DAgostino
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $1,979,793
- **Award type:** 1
- **Project period:** 2020-08-01 → 2022-07-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10111923

## Citation

> US National Institutes of Health, RePORTER application 10111923, Limited Competition for the Closeout of the SEARCH for Diabetes in Youth Cohort Study (1R01DK127208-01). Retrieved via AI Analytics 2026-05-27 from https://api.ai-analytics.org/grant/nih/10111923. Licensed CC0.

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