# Alzheimer's Disease Patient Registry (ADPR/ACT)

> **NIH NIH U01** · KAISER FOUNDATION RESEARCH INSTITUTE · 2020 · $3,102,857

## Abstract

SUMMARY
The overarching goal of this project is to deepen our understanding of the aging brain in a well characterized
community-based longitudinal prospective cohort study. The Adult Changes of Thought (ACT) study enrolled a
cohort of 2,581 Group Health participants in 1994-1996, an expansion cohort of 811 in 2000-2002, and in 2005
began continuous enrollment to keep 2,000 people alive and at risk for dementia outcomes; total enrollment to
date is more than 5,700. Extensive and unmatched clinical and research study data are available for study
participants. Autopsy consent is sought; 850 autopsies have been completed to date, and more than a third of
active participants have signed autopsy consents. Investigators propose three aims. Aim 1 addresses
MULTIMORBIDITY: the single and joint effects of blood pressure, glucose, and cholesterol, and their
treatments, on the aging brain. Outcomes include time to dementia and Alzheimer’s disease, cognitive
functioning, standard neuropathological indices, and newly developed quantitative measures of regional Aβ,
tau, and synaptophysin. This aim leverages important methodological innovations, including hierarchical
Bayesian modeling of exposure trajectories to incorporate sporadically collected clinical data, modern
psychometric approaches to cognitive data, use of marginal structural models to account for selection bias for
autopsy studies, new criteria for neuropathological assessment of AD, and the newly developed quantitative
measures of neuropathology. Aim 2 addresses RESILIENCE: why some people do well despite factors
associated with doing poorly. Aim 2a addresses the role of physical activity on trajectories of cognition and
physical performance, using accelerometers to address the amount and type of activity associated with
protection. Aim 2b addresses factors associated with living to age 85 while preserving cognition and mobility,
specifically focusing on physical activity and on medical comorbidity. Aim 2c addresses factors associated with
avoiding dementia despite accumulation of neuropathology. In particular, Aim 2c will focus on synaptic
contents, applying flow cytometry of a synaptosome preparation. Aim 3 addresses a LIVING LABORATORY:
continuing to serve as a resource to researchers around the world.

## Key facts

- **NIH application ID:** 10112081
- **Project number:** 3U01AG006781-31S1
- **Recipient organization:** KAISER FOUNDATION RESEARCH INSTITUTE
- **Principal Investigator:** Paul K Crane
- **Activity code:** U01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $3,102,857
- **Award type:** 3
- **Project period:** 1986-09-30 → 2021-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10112081

## Citation

> US National Institutes of Health, RePORTER application 10112081, Alzheimer's Disease Patient Registry (ADPR/ACT) (3U01AG006781-31S1). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10112081. Licensed CC0.

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