# Convergence of myeloid susceptibility protein function in Alzheimer's disease

> **NIH NIH RF1** · COLUMBIA UNIVERSITY HEALTH SCIENCES · 2020 · $141,764

## Abstract

PIs: Bradshaw, Elizabeth M., Ph.D.
Title: Convergence of myeloid susceptibility protein function in Alzheimer’s disease
Project Summary/Abstract
Alzheimer’s disease is an age-related neurodegenerative disease characterized by progressive
cognitive decline and dementia. Genome-wide association studies and sequencing studies have
identified novel Alzheimer’s disease susceptibility loci. Interestingly the associated genes at several of
these loci implicate the immune system in late-onset Alzheimer’s disease, specifically the innate
immune system. However, how the majority of the proteins derived from these genetically associated
loci actually function in immune cells is still unknown, especially in the context of Alzheimer’s disease.
We have identified eight genetically associated proteins, which may be working together in a tyrosine
phosphorylation signaling pathway in innate immune cells. For this application, we propose a
multifaceted approach to 1) identify the interacting proteins of these eight Alzheimer’s disease
genetically associated proteins, which we believe function together in microglia, and for which we
already have strong supporting evidence of a shared pathway 2) validate that the proteins are
phosphorylated and that the interactions occur in situ in the Alzheimer’s disease brain, and finally 3)
Dissect the signaling pathway in vitro to understand functional outcomes and pinpoint intervention
points.

## Key facts

- **NIH application ID:** 10112572
- **Project number:** 3RF1AG058852-01S1
- **Recipient organization:** COLUMBIA UNIVERSITY HEALTH SCIENCES
- **Principal Investigator:** Elizabeth M Bradshaw
- **Activity code:** RF1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $141,764
- **Award type:** 3
- **Project period:** 2018-04-15 → 2023-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10112572

## Citation

> US National Institutes of Health, RePORTER application 10112572, Convergence of myeloid susceptibility protein function in Alzheimer's disease (3RF1AG058852-01S1). Retrieved via AI Analytics 2026-06-01 from https://api.ai-analytics.org/grant/nih/10112572. Licensed CC0.

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