# Shared Resource: Genomics Facility

> **NIH NIH P30** · RESEARCH INST OF FOX CHASE CAN CTR · 2020 · $8,696

## Abstract

CELLULAR/MOLECULAR ANALYSES SHARED RESOURCE: GENOMICS FACILITY (GF)
PROJECT SUMMARY/ABSTRACT
The Genomics Facility (GF) provides cost-effective, high-quality genomic and epigenetic services that facilitate
the science of Cancer Center members. The GF is under the direction of Joseph Testa, PhD (CB), and
supported by 3 FTE Managers and 1.35 FTE technical staff. The GF offers three major research service Units:
Research Cytogenetics and Chromosome Microarray Analysis (CMA), Expression Microarray and NextGen
Sequencing; and Genotyping & Real-Time PCR. The GF is located in contiguous laboratory space on the 3rd
floor of the Robert C. Young, MD Pavilion, a location that is centrally located and easily accessible to all
Cancer Center members. The GF addresses the genomic and gene expression needs of Cancer Center
members, many of whom conduct research aimed at understanding the genetic and epigenetic underpinnings
of tumor formation and progression. The GF assists investigators to unravel biomarkers or molecular
signatures of cancer that may improve patient care by affording advances in the early detection, diagnosis and
treatment of cancer, important FCCC objectives. Additionally, the GF holds several scientific and technical
seminars annually to present applications of new genomic platforms for cancer research. Overall, the services
provided by the GF are a valuable resource, as they help to support research efforts in all five Research
Programs and sustain the translational research objectives of the Center. 41 Cancer Center members used the
GF in calendar year 2014, of which 88% had peer-review-funded grants. 63 Cancer Center members from all 5
Research Programs used the GF in the period 2011-2014. The experience of the Facility Director, Testa, is
key in implementing state-of-the-art technology and new approaches. Testa's leadership coupled with
investment of $42,000 led to upgrading the Illumina HiSeq2500. The HiSeq 2500 can perform a full line of high
throughput sequencing applications and is capable of generating 600 GB of data in 11 days in the high output
mode and 120 GB in 1 day in the rapid mode. The Center also provided funds of $231,000 for a nanoString's
nCounter Analysis System that enables the profiling of hundreds of mRNAs, microRNAs, or CNVs
simultaneously with high sensitivity and precision. The primary benefits of the platform are the ability to
complete studies faster and with very high precision. A major value added of the GF is that it is the most cost
effective way to provide users with advanced technologies that are too costly to purchase and support by any
individual lab. The GF staff provides stability by ensuring users access to properly functioning instruments. The
GF is advised by a dedicated Facility Advisory Committee (FAC) that meets at least annually.
Recommendations from the FAC are directed to a governing Facility Parent Oversight Committee (FPOC) that
serves to ensure that the GF continues to have the necessary res...

## Key facts

- **NIH application ID:** 10113005
- **Project number:** 3P30CA006927-54S4
- **Recipient organization:** RESEARCH INST OF FOX CHASE CAN CTR
- **Principal Investigator:** Joseph R. Testa
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $8,696
- **Award type:** 3
- **Project period:** — → —

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10113005

## Citation

> US National Institutes of Health, RePORTER application 10113005, Shared Resource: Genomics Facility (3P30CA006927-54S4). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10113005. Licensed CC0.

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