# Confirming P1 as a Stable Biomarker of Attention to Social Threat in Peri-Pubertal Youth

> **NIH NIH R01** · FLORIDA INTERNATIONAL UNIVERSITY · 2020 · $123,006

## Abstract

Project Summary
 This 2-site (Florida International University, Yale University) proposed funded Administrative Supplement to
Pettit/Silverman R01, Targeting Attention Orienting to Social Threat to Reduce Social Anxiety in Youth, aims to
increase the sustained impact of the project and falls within the scope of the current award. Our primary aim is
to collect Supplemental data to firmly establish stability of the study's putative target mechanism, the rapidly
deployed attention-associated neural processes measured via event-related potentials (ERPs) (i.e., P1
amplitudes for socially threatening stimuli in peri-pubertal youth ages 10 to 14 years). We will collect
Supplemental data using a broadened sampling frame of 70 additional youths (35 per site) across a continuum
of social anxiety symptom severity, in line with the Research Domain Criteria (RDoC) framework. We will use
the same Parent Grant assessment points: PRE, MID (two weeks after PRE), POST (four weeks after PRE),
and FOLLOWUP (6 Months after POST). The Supplemental participants will be involved only in the study's
assessment procedures, unlike Parent Grant participants who are randomized to either (1) Attention Bias
Modification Treatment (ABMT) or (2) Neutral Control Task (NCT). We will evaluate (1) within-subject stability
among the Supplemental participants who receive no intervention, and (2) between-subject stability by
comparing Supplemental participant data with Parent Grant participant data. There has never been a stability
study of our project's putative target P1 amplitudes for socially threatening stimuli in youth (or adults), aside
from our preliminary data (test-retest reliability of r = .50 over 8 weeks). Collecting these Supplemental data is
therefore critical to establish firmly the target's stability and will benefit the experimental therapeutics approach
by providing novel confirmatory support for the mechanistic role of ERP P1 amplitudes in attention training
protocols in a broad sample of youth whose social anxiety symptoms are assessed dimensionally. Data
documenting within-subject stability among Supplemental participants, together with data from the Parent
Grant demonstrating P1 reductions in youth who receive attention training, would provide novel convergent
data, establishing more firmly the stability and plasticity of this target in the critical developmental window of
peri-puberty. These data will further facilitate our efforts to translate ERP effects from the Parent Grant into
clinically interpretable effects. This is because these Supplemental data from a broadened sample of youth
across a continuum of social anxiety severity will provide a benchmark against which to compare ERP P1
amplitudes in youth with social anxiety disorder prior to attention training. They also will allow us to determine
whether attention training in youth with social anxiety disorder results in ERP P1 amplitudes comparable with
those found in a broadened, nonreferred sample of you...

## Key facts

- **NIH application ID:** 10113096
- **Project number:** 3R01MH119299-02S1
- **Recipient organization:** FLORIDA INTERNATIONAL UNIVERSITY
- **Principal Investigator:** JEREMY W PETTIT
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $123,006
- **Award type:** 3
- **Project period:** 2019-04-17 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10113096

## Citation

> US National Institutes of Health, RePORTER application 10113096, Confirming P1 as a Stable Biomarker of Attention to Social Threat in Peri-Pubertal Youth (3R01MH119299-02S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10113096. Licensed CC0.

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