# Tulane National Primate Research Center, AIDS SPF Breeding Colony Maintenance

> **NIH NIH U42** · TULANE UNIVERSITY OF LOUISIANA · 2020 · $499,999

## Abstract

Project Summary Overall
The Tulane National Primate Research Center (TNPRC) has one of the largest rhesus monkey breeding colonies
in the US. The TNPRC U24 supported SPF colony is also notable because it is one of only three NIH
supported SPF macaque colonies that includes an expanded SPF (eSPF) colony negative for up to five
additional agents (total of nine). The objective of this application is to request funds for continued support and
maintenance of the U24 supported SPF Indian-origin rhesus monkey breeding colony at the TNPRC. As directed
by ORIP and in response to the FOA, the current U24 funding mechanism supporting the colony will be converted
to a U42 mechanism with this application. Production will be moderately increased in the next few years based
on recent developments in funding and animal demand. The specific aims address the components specified in
the funding opportunity announcement (FOA) and are divided into the overall program description, husbandry
core, viral testing core and genetics/MHC core. Program income (and TNPRC funds) will be used to fund
components of the program not covered by grant funds including: per diem for any colony animals in excess of
the animals supported by this application, additional testing required for those animals, infrastructure repairs and
improvements, veterinary clinical and pathology support, behavioral management support, and portions of the
genetic testing.
Specific Aims:
Overall. To maintain the existing SPF colony and distribute available animals to the NIH funded AIDS research
community.
Husbandry and Management. To provide husbandry and veterinary care for the SPF breeding colony
established in the existing U24 grant. This includes a robust program for clinical veterinary medical care and
behavioral management. The colony has reached a mature self-sustaining status with ideal demographics to
produce up to 190 animals available for assignment each year. Program Income generated by the sale of
animals will be returned to an account for use in supporting the aims of the grant.
Viral Testing. To assure the SPF status of the colony through continued viral testing of existing breeding colony
animals and all offspring. Continue to expand characterization of the colony beyond the required 4 or 9 (eSPF)
viruses to include agents such as measles virus, Chickungunya virus, Zika virus, Trypanosoma cruzi and other
emerging infectious diseases that threaten nonhuman primates.
Genetic/MHC typing. To continue genetic analysis and MHC typing of the colony and provide expanded genetic
characterization through enhanced techniques.

## Key facts

- **NIH application ID:** 10113202
- **Project number:** 3U42OD024282-03S1
- **Recipient organization:** TULANE UNIVERSITY OF LOUISIANA
- **Principal Investigator:** RUDOLF Paul BOHM
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $499,999
- **Award type:** 3
- **Project period:** 2017-07-01 → 2021-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10113202

## Citation

> US National Institutes of Health, RePORTER application 10113202, Tulane National Primate Research Center, AIDS SPF Breeding Colony Maintenance (3U42OD024282-03S1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10113202. Licensed CC0.

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