# Protocol Review and Monitoring System

> **NIH NIH P30** · MAYO CLINIC ROCHESTER · 2021 · $203,477

## Abstract

PROTOCOL REVIEW AND MONITORING SYSTEM PROJECT SUMMARY
The Mayo Clinic Cancer Center (MCCC) provides oversight for the scientific aspects and performance of
cancer interventional clinical trials conducted at Mayo Clinic through the Center's Protocol Review and
Monitoring System (PRMS). The focus of the PRMS is on scientific merit, priorities, and progress of the clinical
research protocols conducted at the MCCC. The Scientific Review Committee (SRC) uses a consistent and
defined process for scientific review that is achieved through established written review criteria, common
reporting forms, and defined expectations. The SRC has responsibility for the approval and/or disapproval of
each study, as well as for the final decision concerning prioritization. To accommodate the increasing
complexity and volume of trials, 4 SRC subcommittees cover trials in hematology and solid tumors with drug-
predominant therapy, radiation-predominant therapy, and surgery-predominant therapy, respectively.
Another subcommittee of the SRC, the Scientific Progress Review Subcommittee (SPRC), reviews
modifications and amendments for approved and active studies. If the modification or amendment proposes
significant changes to the scientific components of a trial, SPRC may request that the SRC review the change
and determine if it is appropriate for the trial to remain active and for the modification or amendment to be
implemented. SPRC also monitors accrual to interventional trials to ensure adequate scientific progress. If
accrual is not adequate, SPRC will initially work with the investigator to determine the reasons. If progress is
not made and there is no reasonable expectation that changes will occur, SPRC forwards the study to SRC for
consideration of closure.
The MCCC PRMS is under the governance of the MCCC Clinical Research Committee, which is chaired by the
Deputy Director for Clinical Research. The Clinical Research Committee reviews and approves the leadership
and membership of each SRC subcommittee at least annually. It also provides guidance on standard scientific
review and administrative processes for SRC and SPRC and reviews the metrics from these committees
quarterly.

## Key facts

- **NIH application ID:** 10113629
- **Project number:** 5P30CA015083-47
- **Recipient organization:** MAYO CLINIC ROCHESTER
- **Principal Investigator:** ANGELA DISPENZIERI
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $203,477
- **Award type:** 5
- **Project period:** 1997-04-25 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10113629

## Citation

> US National Institutes of Health, RePORTER application 10113629, Protocol Review and Monitoring System (5P30CA015083-47). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10113629. Licensed CC0.

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