# O-Specific Polysaccharide Responses and Cholera

> **NIH NIH R56** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $248,922

## Abstract

PROJECT SUMMARY
Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to
5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera
vaccines have shortcomings. They are often poorly immunogenic in children under the age of 5
years, and often do not induce robust long-term memory responses in immunologically naïve
populations. We provide strong preliminary data that antibodies targeting O-specific polysaccharide
(OSP) affect Vibrio cholerae and are associated with protection against cholera. We here propose an
international clinical study approach to investigate the impact of OSP-specific antibodies on V.
cholerae.

## Key facts

- **NIH application ID:** 10113785
- **Project number:** 2R56AI106878-06
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Edward T. Ryan
- **Activity code:** R56 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $248,922
- **Award type:** 2
- **Project period:** 2013-08-07 → 2020-09-14

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10113785

## Citation

> US National Institutes of Health, RePORTER application 10113785, O-Specific Polysaccharide Responses and Cholera (2R56AI106878-06). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10113785. Licensed CC0.

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