# Defining Pathway-Specific Kinase Signaling Modules with Proteomics

> **NIH NIH R01** · UNIVERSITY OF WASHINGTON · 2021 · $395,242

## Abstract

Abstract
Protein phosphorylation by kinases is an important regulatory modification that controls many cellular
processes. Advances in tools and approaches to study this modification have greatly expanded the catalog of
known phosphorylation sites but there remain substantial gaps in our knowledge. We will apply novel kinome-
centric analyses to study canonical cell signaling pathways in order to define pathway-specific signaling
modules. Our goal is to develop a mass spectrometry-based phenotyping assay that can identify
phosphosignatures of cell signaling.

## Key facts

- **NIH application ID:** 10115079
- **Project number:** 5R01GM129090-03
- **Recipient organization:** UNIVERSITY OF WASHINGTON
- **Principal Investigator:** Shao-En Ong
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $395,242
- **Award type:** 5
- **Project period:** 2019-05-01 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10115079

## Citation

> US National Institutes of Health, RePORTER application 10115079, Defining Pathway-Specific Kinase Signaling Modules with Proteomics (5R01GM129090-03). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10115079. Licensed CC0.

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