# Bioinformatics and Biotechnology Shared Resource Core

> **NIH NIH P30** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2021 · $886,872

## Abstract

PROJECT SUMMARY/ABSTRACT—Bioinformatics and Biotechnology Shared Resource
The goal of the Bioinformatics and Biotechnology Shared Resource (BBSR) is to provide the latest innovative,
high-throughput biotechnology and bioinformatics methods and approaches to support the cancer research of
SJCCC members. The Bioinformatics team provides expert data analysis by utilizing a SJCCC genomic-analysis
infrastructure developed and validated through the Pediatric Cancer Genome Project. The Biotechnology team
provides state-of-the-art high-throughput genomic assays of RNA and DNA samples by using 3 complementary
platforms: genome sequencing, Sanger sequencing, and microarray analysis. The BBSR is directed by Dr.
Jinghui Zhang (CBP), Chair of the Department of Computational Biology, who has more than 20 years of
research experience in genetic variant characterization in the human genome. She is recognized worldwide for
her expertise in the development of novel algorithms, data visualizations, and analyses for deciphering sequence-
variation data in pediatric cancer. She is assisted by Dr. Geoffrey Neale, who is responsible for management and
scientific oversight of the biotechnology laboratories. He has more than 25 years of experience in scientific
management and the investigation of pediatric cancer using molecular techniques. The BBSR is further staffed
by a group of PhD-level expert scientists with varied specialization and domain knowledge to support SJCCC
projects. Services include technical and analytical support for state-of-the-art molecular profiling, such as next-
generation sequencing, microarrays, single-cell sequencing, and CRISPR screening, as well as expert
consultation and advisory support. The impact of the BBSR on SJCCC research is evidenced by the significant
contribution to publications, many in high-impact journals such as the New England Journal of Medicine, Nature,
Nature Genetics, Cell, and Lancet. During the project period, the BBSR supported all 5 SJCCC Programs,
resulting in 418 publications, which represent 20.2% of the total publications from the SJCCC during this period.
The BBSR was used by 65 SJCCC members, 70% (n=46) of whom have cancer-relevant, peer-reviewed
funding. In the next project period, the BBSR will actively evaluate new technology and analytical methods. New
standard services and technology, such as Novaseq, will be introduced for SJCCC members. We will also
continue to work with the SJCCC Programs to establish new molecular-profiling technology and to pursue
bioinformatics method development in areas including network analysis; long-read technology (PacBio and
Oxford Nanapore); single-cell RNA-Seq (DropSeq) and VDJ solution from 10X Genomics; and long-range
chromatin-interaction assays (eg., Hi-C, HiChip, and Capture-C). Finally, we will continue deploying workflows
to the newly established St. Jude Cloud platform, a Blue Sky initiative, to provide bench scientists within the
SJCCC and around the world with direc...

## Key facts

- **NIH application ID:** 10116299
- **Project number:** 5P30CA021765-42
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** Jinghui Zhang
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $886,872
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10116299

## Citation

> US National Institutes of Health, RePORTER application 10116299, Bioinformatics and Biotechnology Shared Resource Core (5P30CA021765-42). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10116299. Licensed CC0.

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