# Developmental Funds

> **NIH NIH P30** · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · 2021 · $813,016

## Abstract

PROJECT SUMMARY/ABSTRACT—Developmental Funds
During the current reporting period (2013 - 2017), SJCCC awarded $4,060,094 in Developmental Funds to meet
two Specific Aims: to support pilot projects for new and established SJCCC investigators, and to support
developing Shared Resources. In the pilot project category, $3,834,745 was awarded to 33 pilot projects,
representing a 62% increase over the previous funding period. In the developing Shared Resource category,
$225,349 was awarded to one developing Shared Resource: Radiation Dosimetry Core. Of the $4,060,094 total
distributed to pilot projects and the developing Shared Resource, $2,101,243 (52%) came from CCSG funds and
$1,958,851 (48%) was provided by the institution. These 33 pilot projects have had a significant impact in the
Center by establishing the laboratory and research programs of new members including Moldoveanu (CBP)
and Zhu (DBSTP); promoting interprogrammatic collaborations such as work from Yang and Robinson (HMP,
NBTP) and intraprogrammatic collaborations such as Gawad's work with Inaba, Pui, Mullighan, Evans and
Yang (HMP); translating findings into clinical protocols such as the BMNIRN trial (NCT02392793) based on
findings from Shelat (CBP); and supporting unique external collaborations such as melanoma studies from
Pappo (DBSTP) and Dr. John Kirkwood of UPMC Hillman Cancer Center. External awards received by pilot
project recipients during the reporting period that resulted from data generated by Developmental Funds support
totals $19,913,112, a 1:5 return on investment. Advances across Programs from pilot projects include Mittag's
(CBP) study on the biophysical mechanisms of Gli ubiquitination in shaping Hedgehog signaling in cancer
(successful R01 application); McKinney-Freeman's (CBP) work on NFI genes in hematopoietic stem cells
(successful R01 application); Moldoveanu's (CBP) identification of BCL-2 family functions (publications in Cell
and Nature Cell Biology); Zuo's (NBTP) discovery regarding the otoprotective effect of amifostine against
cisplatin-induced hearing loss (successful R01 application); Northcott's (NBTP) characterization of transcription
factor mutations as drivers in pediatric medulloblastoma (publication in Nature and $600,000 in grant support);
Klco's (HMP) identification of genomic alterations in pediatric myelodysplastic syndromes (Nature
Communications); Yang and Robinson's (HMP, NBTP) interprogrammatic project on inherited genetic
variations in susceptibility to platinum ototoxicity (Nature Genetics); and Federico's (DBSTP) project targeting
the P13K pathway in neuroblastoma that provided the foundation for Stewart et al., Nature 2017. Future plans
include a special emphasis on funding clinical and population science research through the pilot project
mechanism and support of a developing Shared Resource, the Center for Advanced Genomic Editing (CAGE).
This Shared Resource was established to provide expertise and infrastructure to educate, assist,...

## Key facts

- **NIH application ID:** 10116328
- **Project number:** 5P30CA021765-42
- **Recipient organization:** ST. JUDE CHILDREN'S RESEARCH HOSPITAL
- **Principal Investigator:** CHARLES ROBERTS
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $813,016
- **Award type:** 5
- **Project period:** 1997-04-01 → 2024-02-29

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10116328

## Citation

> US National Institutes of Health, RePORTER application 10116328, Developmental Funds (5P30CA021765-42). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10116328. Licensed CC0.

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