# High-Throughput Screening and Computational Chemistry Core

> **NIH NIH P20** · UNIVERSITY OF NEBRASKA MEDICAL CENTER · 2021 · $45,522

## Abstract

Project Summary/Abstract: High-Throughput Screening and Computational Chemistry Core (Core 1)
The objective of the High-Throughput Screening and Computational Chemistry Core (HTSCC) is to contribute
to the mission of the Nebraska Center for Molecular Target Discovery and Development (MTDD) by providing
the critical functional infrastructure, reagents, instrumentation, technical expertise, and training necessary for
MTDD investigators to conduct their research projects. By conducting high-throughput siRNA, chemical, and
virtual in silico screening experiments, investigators have a novel and powerful tool to rapidly and efficiently
generate accurate information about gene pathways and functions, as well as to identify small molecule
inhibitors that can serve as reversible chemical probes to dissect these signaling pathways, along with the
possibility of identifying lead compounds for drug discovery. These activities are generally not practical for the
individual research laboratory to carry out for reasons of cost or lack of specialized technical skills and/or
equipment. For MTDD investigators interested in using HTS and high-content imaging (HCI) services, the
ability to add automation, miniaturize assays, and incorporate instrumentation designed for high-throughput
can greatly reduce reagent, plastic-ware, and labor costs for a vast array of screening and non-screening
experimentation performed in their laboratories. An additional benefit is that the scope of investigator
experimentation can be greatly broadened and performed with greater precision, typically enhancing the
quality and reproducibility of data. Throughout this process, on-site staff provides expertise, training, support,
and feedback in the performance of screening technologies that will minimize costs, enhance throughput, and
maximize the generation of interpretable results. Moreover, the core will continually develop and implement
new technologies as needed and work to obtain and/or upgrade necessary instrumentation. By these means,
the core will help to make MTDD investigators more competitive for research funding and to facilitate the long-
term goal of performing research that ultimately results in the improvement of the health of patients.

## Key facts

- **NIH application ID:** 10117096
- **Project number:** 5P20GM121316-04
- **Recipient organization:** UNIVERSITY OF NEBRASKA MEDICAL CENTER
- **Principal Investigator:** David Lee Kelly
- **Activity code:** P20 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $45,522
- **Award type:** 5
- **Project period:** 2018-03-16 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10117096

## Citation

> US National Institutes of Health, RePORTER application 10117096, High-Throughput Screening and Computational Chemistry Core (5P20GM121316-04). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10117096. Licensed CC0.

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