# Center for the Study of Complex Malaria in India

> **NIH NIH U19** · NEW YORK UNIVERSITY · 2021 · $747,214

## Abstract

OVERALL SUMMARY
In India, the world's largest democracy and second most populous country, malaria remains an enormous
public health problem. Malaria in India is 'complex'; two predominant species of parasite may be present
serially or concurrently in one person. Each species also has multiple strains (genotypes) that can serially or
concurrently infect. Indian malaria complexity, its variation by location, and its consequences for malaria
immunity and severity, are the research focus of the CSCMi. The aims of the Center are to develop the
knowledge, tools, and evidence-based strategies needed to support Indian intervention and control programs,
and to build research capacity in India. CSCMi research comprises three projects: Project 1: Epidemiology of
malaria and infection dynamics, Project 2: P. vivax diagnosis, genomics and biology, and Project 3:
Pathogenesis of cerebral malaria. Project 1 will undertake census, cross-sectional surveys, survey-cohorts,
and clinic-based cohort studies for malaria baseline epidemiology and identification of asymptomatic n=and
relapse individuals at our three ecologically and epidemiologically diverse field sites in Sundergarh District,
Odisha, West Garo Hills in Meghalaya, and Jaintia Hills in Meghalaya. It will use biological samples collected
during these studies to assess how infection complexity impacts seroepidemiology and CD4+ immune
signatures in asymptomatic versus clinical malaria. Project 2 will investigate biomarkers of P. vivax hypnozoite
infection, and deploy real-time genomics methods of diagnosis and for population genomics. Project 3 will use
magnetic resonance imaging techniques to study cerebral malaria pathogenesis in an unprecedented and
comprehensive comparative analysis between patients in India and Malawi, and investigate molecular
pathogenetic mechanisms of disease. The CSCMi projects will be supported by an Administrative Core and
Data Management and Biostatistics Core, and advised by a team of consultants and a Scientific Advisory
Group.

## Key facts

- **NIH application ID:** 10117151
- **Project number:** 5U19AI089676-12
- **Recipient organization:** NEW YORK UNIVERSITY
- **Principal Investigator:** JANE M CARLTON
- **Activity code:** U19 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $747,214
- **Award type:** 5
- **Project period:** 2010-07-01 → 2024-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10117151

## Citation

> US National Institutes of Health, RePORTER application 10117151, Center for the Study of Complex Malaria in India (5U19AI089676-12). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10117151. Licensed CC0.

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