# Functional Genomics & Microbiome Core

> **NIH NIH P30** · BAYLOR COLLEGE OF MEDICINE · 2021 · $194,163

## Abstract

Project Summary 
The Functional Genomics and Microbiome Core (Core C) supports the mission of the DDC and 
enhances research programs in its theme of infection and injury affecting the mammalian intestine and 
liver. We continue to enhance the scope of the Core, based on DDC user demand and our firm 
commitment to the importance of the microbiome in gastrointestinal and liver biology. The emphasis of 
this Core is on functional genomics and how genes present in the mammalian microbiome and in 
mouse/human genomes may yield functional RNAs, proteins and metabolites that help stitch together 
a deeper and mechanistic understanding of digestive diseases. Our mission is to provide a full-service 
resource from experimental design to consultations about specimen processing, robust data analysis 
pipelines, bioinformatics strategies, and biostatistical support. In summary, we have created a fully 
integrated genomic and multi-`omic analysis platform for investigators studying digestive diseases. This 
Core serves DDC investigators by providing expertise in microbial and mammalian genomics, 
transcriptomics, metabolomics and protein analytics, as applied to gastrointestinal infection and injury 
states. Research programs nurtured by DDC members are facilitated by this Core's ability to bridge 
microbiome science and mammalian biology, and to provide multi-tiered services at the levels of genes 
and effectors (proteins and metabolites). This Core deploys the tools/services of microarrays, deep 
nucleic acid sequencing (microbial and mammalian), protein multiplexing, mass spectrometry-guided 
metabolomics, and bioinformatics. PCR-based analyses of gene expression and splicing, DNA 
mutation/SNP detection, and gene pathway analyses of the mammalian metagenome (microbe and 
man) will be fostered by this Core as a platform for gastrointestinal and hepatic systems biology. This 
Core presents a combination of shared as well as exclusive offerings to TMC DDC members. The 
Microbiome and Mammalian Genomics services provide valuable capital-intensive resources shared 
among DDC and non-DDC members at BCM. DDC members account for about 10% of institutional 
usage of metagenomics and mammalian genomics services. The Metabolomics/Mass Spectrometry, 
Protein Multiplexing, and Bioinformatics services are TMC DDC member-exclusive services, not offered 
to non-DDC members as Core functions.

## Key facts

- **NIH application ID:** 10117231
- **Project number:** 5P30DK056338-19
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** James Versalovic
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $194,163
- **Award type:** 5
- **Project period:** 2001-04-15 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10117231

## Citation

> US National Institutes of Health, RePORTER application 10117231, Functional Genomics & Microbiome Core (5P30DK056338-19). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10117231. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*