# Clinical Core

> **NIH NIH P30** · JOHNS HOPKINS UNIVERSITY · 2021 · $328,328

## Abstract

PROJECT SUMMARY - CLINICAL CORE 
The prevalence of HAND in HIV+ individuals with advanced infection remains around 40-50%, and HAND may 
now be the most common form of young-age neurocognitive impairment globally. Currently there are no 
uniformly accepted clinical, neuroimaging, or laboratory outcome measures for clinical trials for the treatment of 
HAND. This Core provides the support necessary to evaluate new outcome measures of CNS function including 
both neurocognitive assessments (e.g., screening tests for HAND) and performance based functional 
assessments. In addition, the Core will provide well-characterized individuals for developmental projects such 
as novel neuroimaging outcomes which may be more sensitive to CNS dysfunction and response to treatment 
than neuropsychological test measures. The Clinical Core will also provide well-characterized individuals for 
evaluating novel laboratory markers identified in the Biomarker Core. Specifically, we will examine markers of 
cell stress, neuronal injury, and energy metabolism, which are also being used as platforms for therapeutic 
targets in our Therapeutic Core. The goals and objectives of this Core are as follows: 1) To maintain a clinical 
cohort of well-characterized HIV+ and demographically-matched HIV- individuals to improve the efficiency of 
accruing and conducting clinical trials, 2) To liaise with other NIMH Centers, other funded IPCPs, the AIDS 
Clinical Trials Group (ACTG), the Johns Hopkins University Center for AIDS Research (JHU CFAR), Institute for 
Clinical and Translational Research (ICTR), and the Johns Hopkins University (JHU) Drug Discovery unit to 
assist in the development of interventional therapeutics for HAND, 3) To provide the infrastructure and resources 
necessary to conduct small early phase studies to evaluate therapeutics for HAND including novel drugs, 
neuromodulation and behavioral strategies, 4) To maintain a data infrastructure to allow for efficient querying of 
clinical and laboratory data, 5) To provide statistical support for all studies involving the Center Grant resources.

## Key facts

- **NIH application ID:** 10118203
- **Project number:** 5P30MH075673-15
- **Recipient organization:** JOHNS HOPKINS UNIVERSITY
- **Principal Investigator:** Leah Helane Rubin
- **Activity code:** P30 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $328,328
- **Award type:** 5
- **Project period:** 2006-04-01 → 2022-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10118203

## Citation

> US National Institutes of Health, RePORTER application 10118203, Clinical Core (5P30MH075673-15). Retrieved via AI Analytics 2026-05-29 from https://api.ai-analytics.org/grant/nih/10118203. Licensed CC0.

---

*[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*