# Alzheimer's-Focused Administrative Supplement

> **NIH NIH R01** · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · 2020 · $248,970

## Abstract

Abstract
 The nuclear lamina is a meshwork of intermediate filaments adjacent to the inner nuclear membrane, integral
to all metazoan cells. It performs a critical structural role in the maintenance of nuclear architecture and
integration of cytoskeletal structure in addition to aiding in regulation of gene expression, chromatin positioning,
cell proliferation, migration and senescence. Exciting, recent work in Drosophila models and from Alzheimer’s
diseases (AD) brain tissue has implicated a down regulation, specifically of B type lamins, and nucleoskeletal
dysfunction as a critical step mediating the neurodegeneration associated with tauopathies such as AD. Lamin
B1 (LB1) is the major B type lamin expressed in the mammalian CNS and loss of this protein during development
results in significant defects in neuronal migration and cortical organization. We propose to test the hypothesis
that overexpression of LB1 in neurons can provide a neuroprotective effect and ameliorate the phenotype in a
mouse model of tau mediated neurodegeneration. The experiments we have proposed will allow us to test the
intriguing possibility that modulating the levels of the nuclear lamina protein, LB1 can impact pathology in a
clinically relevant mouse model of tau mediated Alzheimer’s disease

## Key facts

- **NIH application ID:** 10118339
- **Project number:** 3R01NS095884-05S1
- **Recipient organization:** UNIVERSITY OF PITTSBURGH AT PITTSBURGH
- **Principal Investigator:** Quasar S Padiath
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $248,970
- **Award type:** 3
- **Project period:** 2016-04-01 → 2021-03-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10118339

## Citation

> US National Institutes of Health, RePORTER application 10118339, Alzheimer's-Focused Administrative Supplement (3R01NS095884-05S1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10118339. Licensed CC0.

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