# Female Reproductive Tissue Mapping Center Data Analysis Core

> **NIH NIH U54** · UNIVERSITY OF CALIFORNIA, SAN DIEGO · 2020 · $167,420

## Abstract

SUMMARY
The Data Analysis Core (DAC) of the proposed HuBMAP Female Reproductive Tissue Mapping Center (FR
TMC) will build 3D tissue maps from data generated by the two Organ Specific Projects (OSP1: Placenta; OSP2:
Uterus, Ovary, Fallopian Tube). The DAC will collaborate with the HuBMAP Integration, Visualization &
Engagement Collaboratory (HIVE) to build an atlas of 3D tissue maps in the context of the whole human body.
The DAC will be responsible for data processing, annotation, metadata curation, analysis, and map construction
within the FR TMC. The DAC will interact closely with the OSPs within the FR TMC and will coordinate close
interactions with the other HuBMAP TMCs, HIVE and NIH Program staff. The DAC will ensure that data,
metadata, software and tools will be open, findable, accessible, interoperable, reusable (FAIR) and will maintain
flexibility to adapt processing and analysis capabilities to emerging technologies within the HuBMAP Consortium.
The DAC will assemble a FR TMC Data Release Team comprised of experts in each of the included data
modalities that will interface directly with the HIVE to ensure data quality control, metadata standards and
facilitate data transfer. The DAC will collaborate closely with the HIVE to optimize secondary analysis pipelines
and to implement the Registration User Interface to register tissue sections to reference organs and a Common
Coordinate Framework to fully integrate spatial and molecular data across individuals. As the HIVE and several
of the other TMCs were funded in 2018, we will adopt Consortium-established metadata standards, data quality
metrics, analysis techniques and data structures, with some adjustments to account for the specific tissues and
data types that are unique to the FR TMC.

## Key facts

- **NIH application ID:** 10119156
- **Project number:** 1U54HD104393-01
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN DIEGO
- **Principal Investigator:** Kathleen Marie Fisch
- **Activity code:** U54 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $167,420
- **Award type:** 1
- **Project period:** 2020-09-25 → 2022-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10119156

## Citation

> US National Institutes of Health, RePORTER application 10119156, Female Reproductive Tissue Mapping Center Data Analysis Core (1U54HD104393-01). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10119156. Licensed CC0.

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