# Calcium transport in Yersinia pestis

> **NIH NIH R03** · OREGON STATE UNIVERSITY · 2021 · $74,250

## Abstract

ABSTRACT
 Pathogenic bacteria, such as Yersinia pestis, are exposed to a wide range of environments
within the host and have to be able to adapt to changes in the surrounding environment to establish
an infection. One of the most peculiar features of the Y. pestis physiology and virulence is its
stringent dependence on alkali/alkaline cations, primarily Ca2+. Despite the importance of calcium in
the regulation of Y. pestis virulence factor production, virtually nothing is known about the mechanism
of membrane transport of calcium in this organism. In Y. pestis, several different proteins potentially
mediate the transport of Ca2+ across the bacterial membrane and some of these proteins are
predicted to be able to integrate Ca2+, Na+, and pH homeostasis in this organism. Elucidation of the
role of these transport systems in the physiology and ultimately pathogenicity of Y. pestis will allow the
assessment of their potential as targets for the development of a novel class of antimicrobials with a
completely new mechanism of action.

## Key facts

- **NIH application ID:** 10119237
- **Project number:** 5R03AI148953-02
- **Recipient organization:** OREGON STATE UNIVERSITY
- **Principal Investigator:** Claudia C Hase
- **Activity code:** R03 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $74,250
- **Award type:** 5
- **Project period:** 2020-03-04 → 2023-02-28

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10119237

## Citation

> US National Institutes of Health, RePORTER application 10119237, Calcium transport in Yersinia pestis (5R03AI148953-02). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10119237. Licensed CC0.

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