# Center for Molecular Imaging Technology and Translation (CMITT) Administrative Supplement to P41EB0225440

> **NIH NIH P41** · MASSACHUSETTS GENERAL HOSPITAL · 2020 · $300,523

## Abstract

Project Summary / Abstract for the Center for Molecular Imaging Technology and Translation
The Center for Molecular Imaging Technology and Translation (CMITT) will be a national resource located
within the newly created Gordon Center for Medical Imaging (GCMI) at the Massachusetts General Hospital.
Working within the interdisciplinary environment (e.g., imaging sciences; image reconstruction and processing;
pharmacokinetics) of the Gordon Center, the aim of CMITT is to develop, validate and disseminate cutting-edge
imaging technologies that take advantage of the game-changing capabilities afforded by simultaneous acquisition of
PET and MR. CMITT consists of three Technology Research and Development projects (TR&Ds): TR&D1 aims at
breaking down the resolution barrier in PET. By developing enabling technologies for attenuation and motion field
estimation as well as PSH modeling we can achieve the intrinsic resolution of PET, about 4mm, in the breathing
patient by using novel accelerated MR acquisitions with sparse sampling. TR&D2 will develop the unified statistical
model of joint reconstruction of PET and MR that incorporates the corrections developed in TR&D1. TR&D3 will
develop the pharmacokinetic modeling of physiological processes in simultaneous PET/MR (TR&D3) in quantitative
PET/MR images that enable exploration of molecular physiology.
There is currently no PET-focused Biomedical Technology Resource Center supported by NIBIB. Thus CMITT
seeks to fill a clear national need for PET/MR imaging technology development, one that is agnostic with respect to
commercial platform and, in many instances, applies equally to PET or MR alone. The Resource provides a unique
environment with an interdisciplinary team of highly accomplished scientists, engineers, and clinicians with diverse
expertise in multiple modalities and disciplines that supports service use of the Center's facilities by imaging
scientists throughout the country as well as Europe, Asia and Australia. CMITT will provide extensive training
opportunities for students, post-doctoral fellows, and faculty, and seeks to advance the field of molecular imaging of
normal function and disease through active dissemination of new knowledge and technology.

## Key facts

- **NIH application ID:** 10119783
- **Project number:** 3P41EB022544-04S1
- **Recipient organization:** MASSACHUSETTS GENERAL HOSPITAL
- **Principal Investigator:** Georges El Fakhri
- **Activity code:** P41 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $300,523
- **Award type:** 3
- **Project period:** 2017-09-30 → 2022-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10119783

## Citation

> US National Institutes of Health, RePORTER application 10119783, Center for Molecular Imaging Technology and Translation (CMITT) Administrative Supplement to P41EB0225440 (3P41EB022544-04S1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10119783. Licensed CC0.

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