# Improving Outcomes of Older Adults with Psychosocial Vulnerability Undergoing Major Surgery

> **NIH NIH K76** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2020 · $242,714

## Abstract

SUPPLEMENT PROJECT SUMMARY/ABSTRACT
Among older adults undergoing major surgery, post-operative complications are common and the impact it has
on post-operative recovery is great. This is especially true for older surgical patients with Alzheimer's disease
or its related diseases (PADRD). This administrative supplement builds upon the existing K76 award
(K76AG059931-01A1) granted to PI Dr. Victoria L. Tang, entitled “Improving Outcomes of Older Adults with
Psychosocial Vulnerability Undergoing Major Surgery”. The overall objective of the parent K76 grant's research
plan is to understand the role of psychosocial vulnerability in post-operative outcomes and to develop a pilot
test of a peri-operative intervention to improve the quality of life of older surgical patients. In this supplemental
application, we propose work that is within the scope of the active award. We propose to conduct semi-
structured interviews to understand the peri-operative experience of PADRD and their caregivers and the
impact of surgery on one's quality of life based on exploring the domains of psychosocial, cognitive, and
physical functional well-being. The proposed work is focused on Alzheimer's disease and its related
dementias as it involves the assessment of PADRD undergoing major surgery. Additionally, in accordance
with the World Health Organization's focus on caregivers as an integral component of their global action plan
on dementia, this project incorporates caregivers and the caregiving relationship into the study design. The
proposed work will stimulate additional activity that will lead to progress on Alzheimer's disease and
its related dementias. The proposed project is designed to provide preliminary data to support a compelling
R01 application that will develop and test a peri-operative intervention to improve quality of life for those living
with ADRD and for their caregivers, who provide essential caregiving and support.

## Key facts

- **NIH application ID:** 10119845
- **Project number:** 3K76AG059931-02S2
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Victoria Lai-Yen Tang
- **Activity code:** K76 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $242,714
- **Award type:** 3
- **Project period:** 2019-09-01 → 2024-04-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10119845

## Citation

> US National Institutes of Health, RePORTER application 10119845, Improving Outcomes of Older Adults with Psychosocial Vulnerability Undergoing Major Surgery (3K76AG059931-02S2). Retrieved via AI Analytics 2026-05-23 from https://api.ai-analytics.org/grant/nih/10119845. Licensed CC0.

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