# Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics

> **NIH NIH R01** · MICHIGAN TECHNOLOGICAL UNIVERSITY · 2021 · $346,966

## Abstract

Abstract
The primary objective is to develop an artificial intelligence-centric, quantitative and noninvasive software
platform that can be integrated into 3D angiographic scanners (DSA, CTA or MRA) to provide guidance
regarding the diagnosis and management of intracranial aneurysms (IA). Hemorrhagic stroke secondary to
ruptured IAs leads to significant morbidity and mortality and affects over 35,000 patients on a yearly basis in
the United States. The diagnosis of asymptomatic IAs is on the rise with the increasing use of cerebral
imaging. However, guidance regarding which aneurysms should be treated has not advanced.
Leveraging recent advances in computational science and technology, particularly artificial intelligence, the
proposed software platform built on two enabling technologies can (1) propel automated “patient-specific”
hemodynamic evaluations into the clinical workflow and (2) conduct “data-driven” risk assessments of IA
rupture on an individual basis. Specific research aims are to (1) develop a clinically-oriented CFD platform
that enables automated “patient-specific” hemodynamic evaluations of IAs, (2) investigate data-driven
analytics toward prediction of rupture risk for IAs and (3) evaluate the data-driven analytics in a blind
study.
Once validated, a follow-up R01 project is planned to examine the clinical utility of the proposed software
platform in a prospective clinical study as a single gateway for computer-aided evaluation of cerebral
aneurysms.

## Key facts

- **NIH application ID:** 10121043
- **Project number:** 1R01EB029570-01A1
- **Recipient organization:** MICHIGAN TECHNOLOGICAL UNIVERSITY
- **Principal Investigator:** Jingfeng Jiang
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $346,966
- **Award type:** 1
- **Project period:** 2021-04-07 → 2024-12-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10121043

## Citation

> US National Institutes of Health, RePORTER application 10121043, Personalized Management of Intracranial Aneurysms Using Computer-aided Analytics (1R01EB029570-01A1). Retrieved via AI Analytics 2026-05-25 from https://api.ai-analytics.org/grant/nih/10121043. Licensed CC0.

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