# Alzheimer's-focused Administrative Supplements for NIH Grants that are not focused on Alzheimer's disease.

> **NIH NIH U42** · NATIONAL DISEASE RESEARCH INTERCHANGE · 2020 · $350,192

## Abstract

Program Director/Principal Investigator (Last, First Middle): Bell, Thomas J.
Project Summary:
The development of effective treatments or cures for a wide range of diseases requires translational studies that
are directly relevant to human pathophysiology. The use of human biospecimens plays a key role in accelerating
scientific discoveries in neurological research by providing scientists with a direct experimental model system to
advance understanding of pathogenesis and treatment of neurological disease, including Alzheimer's disease
and related dementias (AD/ADRD). To address several complex issues facing AD/ADRD research, including
disease etiology as well as the development of improved diagnostics and treatment strategies, investigators
require access to a unique human tissue resource that could provide rigorous and uniform collection of human
biospecimens from defined cohorts of both post mortem AD/ADRD donors and living AD/ADRD patients to yield
consistent and reproducible experimental results for inventive and groundbreaking studies. As a leading human
tissue provider for the biomedical research community, the National Disease Research Interchange (NDRI) is a
501(c)(3), not-for-profit organization that remains at the forefront of coordinating biospecimen procurement to
match the needs of advancing scientific experimental methodologies, enabling cutting-edge research. For over
30 years, NDRI has received NIH funding for the parent award to this administrative supplement, the Human
Tissue and Organs for Research Resource (HTORR) Grant Number: U420DO1158. To address the high priority
areas of research for AD/ADRD that require both post mortem and living patient biospecimen collection that are
beyond the scope of HTORR, NDRI is expanding their capabilities to create a new resource, the AD/ADRD
Human Biospecimen Resource (ADBR), funded by the active award 3U42OD011158-28S3. In Program Year 2
of the ADBR, NDRI continued to lead the development of the ADBR Advisory Council to obtain ongoing
recommendations regarding biospecimen collection and distribution for the ADBR that align with an unmet or
under represented need in the field. For the current proposal to continue the progression of the ADBR, NDRI
will: 1) identify and authorize/consent distinct cohorts of non-diseased and AD/ADRD post mortem donors 2)
coordinate the recovery of AD/ADRD biospecimens, 3) distribute biospecimens and donor data to investigators
or store biospecimens to support future high priority area studies, and 4) monitor the performance of the ADBR
and maintain guidance for the resource from an ADBR Advisory Council. In doing so, the biospecimen collection
and preservation methods will be optimized to the experimental hypotheses and procedures for each ADBR
study using NDRI's experience in coordinating standardized procurement, processing, preservation and shipping
methods and maintaining industry best practices and standards regarding the donation of human tissue for
rese...

## Key facts

- **NIH application ID:** 10121141
- **Project number:** 3U42OD011158-30S1
- **Recipient organization:** NATIONAL DISEASE RESEARCH INTERCHANGE
- **Principal Investigator:** Thomas J Bell
- **Activity code:** U42 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $350,192
- **Award type:** 3
- **Project period:** 1989-01-09 → 2023-06-30

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10121141

## Citation

> US National Institutes of Health, RePORTER application 10121141, Alzheimer's-focused Administrative Supplements for NIH Grants that are not focused on Alzheimer's disease. (3U42OD011158-30S1). Retrieved via AI Analytics 2026-05-22 from https://api.ai-analytics.org/grant/nih/10121141. Licensed CC0.

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