# Genetic modifiers of Alzheimer Risk Administrative Supplement

> **NIH NIH UM1** · BAYLOR COLLEGE OF MEDICINE · 2020 · $397,000

## Abstract

Genetic Modifiers of Alzheimer Risk Administrative Supplement
We have identified a blood biomarker signal that differentiates genetically mutant Alzheimer disease (AD)-model
mice from their age- and sex-matched non-mutant littermates: markers of the cellular response to DNA damage.
This supplement to the KOMP project will define the detection limits of the assay signal in time, pre-disease, and
breadth of models detectable, and will examine viable knock-out mice generated in the KOMP project for signal
in the blood assay as a simple screen for knock-outs with AD and pre-AD properties. This work has the potential
to identify new AD risk alleles, and to produce a simple, early initial blood-based biomarker and assay for AD
risk. Simple blood screens for pre-AD phenotypes could allow identification and potentially prevention of
symptoms in at-risk individuals not otherwise identified.

## Key facts

- **NIH application ID:** 10121529
- **Project number:** 3UM1HG006348-10S1
- **Recipient organization:** BAYLOR COLLEGE OF MEDICINE
- **Principal Investigator:** Mary E Dickinson
- **Activity code:** UM1 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2020
- **Award amount:** $397,000
- **Award type:** 3
- **Project period:** 2011-09-28 → 2021-08-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10121529

## Citation

> US National Institutes of Health, RePORTER application 10121529, Genetic modifiers of Alzheimer Risk Administrative Supplement (3UM1HG006348-10S1). Retrieved via AI Analytics 2026-05-26 from https://api.ai-analytics.org/grant/nih/10121529. Licensed CC0.

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