# Socio-spatial Networks and Tuberculosis Infection in Youth in Rural Uganda

> **NIH NIH R01** · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · 2021 · $670,879

## Abstract

PROJECT SUMMARY/ABSTRACT
The burden of tuberculosis (TB) in children and adolescents is massive and current TB control strategies, even
at full scale-up, are insufficient to address it.4,6-8,10 Novel strategies to expand TB control outside of the home
and into the community, where children acquire an estimated 80% of new TB infections,11-12 are urgently
needed. However, an incomplete understanding of where and from whom youth acquire TB, and how these
drivers change throughout the early life-course, hampers the design of novel interventions. Thus, we propose
the first-ever population-representative, longitudinal TB Infection Incidence Cohort of youth ages 1 to 18 years,
in rural communities in Uganda. Using a combination of epidemiologic and network analytic techniques, this
study will address key foundational knowledge gaps about TB transmission within 3 socio-spatial networks of
youth: the household network, the non-household social network (close contacts), and the network of casual
contacts encountered in community venues. In Aim 1 we will characterize the role of the household social
network in TB infection throughout the early life course. In Aim 2 we will employ social network analysis to
assess the relationships between child and adolescent TB infections and their community-based social
network, and in Aim 3 we will use location-based networks to assess the relationships between community
venues and incident TB infections in youth. Data from this proposal will directly inform novel, age-specific,
community-based TB control strategies and will help optimize existing household-based strategies.

## Key facts

- **NIH application ID:** 10121608
- **Project number:** 1R01AI151209-01A1
- **Recipient organization:** UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- **Principal Investigator:** Carina Marquez
- **Activity code:** R01 (R01, R21, SBIR, etc.)
- **Funding institute:** NIH
- **Fiscal year:** 2021
- **Award amount:** $670,879
- **Award type:** 1
- **Project period:** 2020-11-16 → 2025-10-31

## Primary source

NIH RePORTER: https://reporter.nih.gov/project-details/10121608

## Citation

> US National Institutes of Health, RePORTER application 10121608, Socio-spatial Networks and Tuberculosis Infection in Youth in Rural Uganda (1R01AI151209-01A1). Retrieved via AI Analytics 2026-05-24 from https://api.ai-analytics.org/grant/nih/10121608. Licensed CC0.

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