# Improving Response to Malaria Outbreaks in Amazon-Basin Countries > **NIH NIH R01** · DUKE UNIVERSITY · 2021 · $727,906 ## Abstract Abstract The objective of this proposal is to improve malaria response in the Amazon by enhancing knowledge on when where, and which targeted interventions will have the greatest impact. There is a critical need for improved malaria control—since 2011, no region in the world has experienced a larger increase in malaria than the Amazon. Several events contributed to this rise: extreme weather (i.e., El Nino), expanded resource extraction, political unrest in Venezuela, and withdrawal of the Global Fund from South America. The unprecedented malaria resurgence has been particularly high near border regions where migration and poor health care facilitate transmission. The current surveillance system has a 4-week delay in cases reported, which is completely inadequate, resulting in reactive vs. preventive intervention strategies. To respond, our team developed a Malaria Early Warning System (MEWS) with NASA support for Loreto, Peru, where over 90% of malaria cases in Peru occur. The MEWS forecasts outbreaks with >90% sensitivity and >75% specificity 8-12 weeks in advance in sub- regions (EcoRegions using unobserved component models [UCM]) and districts (via spatial Bayesian models), and fits community-based agent based models (ABMs) to evaluate behavioral factors associated with transmission. However, gaps remain: our MEWS has unknown performance outside of Peru; it does not incorporate migration; forecasts are not downscaled for hotspot detection; forecasting performance is poor near border regions; and the models are not integrated across scales. We address these gaps with three aims: (1) Evaluate MEWS expansion to the Ecuadorian and Brazilian Amazon and evaluate sub-district downscaled forecasts; (2) Evaluate the relationship between infrastructure, socioeconomic networks, and migration across international borders with malaria incidence; and (3) Evaluate scenarios of potential malaria interventions along borders to reduce malaria risk in both countries using ABMs. This project will significantly improve current surveillance efforts by providing both current estimates and forecasts of malaria using state-of-the-art climate, hydrology and land cover models. The MEWS is expanded by obtaining surveillance and population data from Ecuador and Brazil, and merging these with hydro-meteorological data. New EcoRegions that ignore administrative borders are defined and UCMs are applied. Spatial Bayesian models are used to estimate both district- and downscaled sub-district level malaria incidence. Infrastructure data are obtained from public sources and a social network analysis (and data collection) will be conducted in communities along border regions (Brazil- Peru, Ecuador-Peru). We evaluate malaria incidence along identified network structures up to 300km away from borders and test simulated intervention scenarios in border communities to evaluate effects on malaria transmission. This proposal responds to the WHO 2016-2030 Global Technical Strategy for ... ## Key facts - **NIH application ID:** 10122016 - **Project number:** 1R01AI151056-01A1 - **Recipient organization:** DUKE UNIVERSITY - **Principal Investigator:** WILLIAM KUANG-YAO PAN - **Activity code:** R01 (R01, R21, SBIR, etc.) - **Funding institute:** NIH - **Fiscal year:** 2021 - **Award amount:** $727,906 - **Award type:** 1 - **Project period:** 2021-09-01 → 2026-08-31 ## Primary source NIH RePORTER: https://reporter.nih.gov/project-details/10122016 ## Citation > US National Institutes of Health, RePORTER application 10122016, Improving Response to Malaria Outbreaks in Amazon-Basin Countries (1R01AI151056-01A1). Retrieved via AI Analytics 2026-05-21 from https://api.ai-analytics.org/grant/nih/10122016. Licensed CC0. --- *[NIH grants dataset](/datasets/nih-grants) · CC0 1.0*